| 12.09.2021 16:55 | Kolubara | 3 : 0 | Novi Pazar | |
| 12.09.2021 16:55 | Radnički (N) | 1 : 0 | Voždovac | |
| 12.09.2021 19:00 | Mladost | 0 : 0 | Čukarički |
| 12.09.2021 16:30 | Budućnost | 2 : 3 | IMT | |
| 12.09.2021 16:30 | Kabel | 1 : 1 | Zlatibor | |
| 12.09.2021 16:30 | Loznica | 2 : 0 | OFK Bačka | |
| 12.09.2021 16:30 | Rad | 2 : 1 | RFK Grafičar | |
| 12.09.2021 16:30 | Inđija | 1 : 0 | OFK Žarkovo |
| 12.09.2021 16:00 | Borac (S) | 3 : 3 | OFK Bečej 1918 |
| 12.09.2021 16:00 | Sušica | 0 : 0 | Trepča | |
| 12.09.2021 19:00 | GFK Sloboda | 2 : 0 | Mladi radnik 1926 | |
| 12.09.2021 16:00 | Rađevac | 0 : 0 | Sloga (K) | |
| 12.09.2021 16:00 | RSK | 2 : 2 | Mačva 1929 |
| 12.09.2021 10:00 | Borac | 1 : 0 | Prva iskra | |
| 12.09.2021 16:00 | Zvezdara | 1 : 1 | Ušće Novi Beograd |
| 12.09.2021 16:00 | Budućnost (P) | 1 : 0 | Meševo | |
| 12.09.2021 16:00 | Dinamo | 1 : 2 | Trayal | |
| 12.09.2021 16:00 | GFK Jagodina | 0 : 1 | Radnički (S) | |
| 12.09.2021 16:00 | Rembas | 3 : 0 | Hajduk Veljko | |
| 12.09.2021 16:00 | Timočanin | 2 : 0 | Radnički (P) | |
| 12.09.2021 16:00 | OFK Brzi Brod | 1 : 0 | Vlasina |
| 12.09.2021 16:00 | Omladinac FAM | 4 : 0 | BAK | |
| 12.09.2021 16:00 | Mladost | 0 : 0 | Kozara | |
| 12.09.2021 16:00 | Vojvodina 1928 | 2 : 1 | Crvena zvezda (RS) |
| 12.09.2021 16:00 | Podunavac | 1 : 1 | Hajduk | |
| 12.09.2021 16:00 | Dunav | 1 : 2 | Sloboda | |
| 12.09.2021 10:00 | Index | 1 : 0 | Cement | |
| 12.09.2021 16:00 | Donji Srem | 0 : 0 | Radnički (NP) |
| 12.09.2021 16:00 | Tavankut | 1 : 0 | Senta | |
| 12.09.2021 16:00 | Vojvodina (BG) | 1 : 1 | Mladost (T) | |
| 12.09.2021 16:00 | SU Stanišić 1920 | 2 : 1 | Mladost (BP) | |
| 12.09.2021 16:00 | Preporod | 1 : 0 | Njegoš |
| 12.09.2021 11:00 | PKB | 0 : 3 | Komgrap | |
| 12.09.2021 16:00 | Poštar Zvezdara | 2 : 4 | Zuce 2019 | |
| 12.09.2021 16:00 | Kosmaj | 1 : 1 | OFK Mladenovac |
| 12.09.2021 16:00 | Budućnost | 0 : 3 | Jošanica | |
| 12.09.2021 16:00 | Korićani | 1 : 1 | Gruža | |
| 12.09.2021 16:00 | Polet | 1 : 1 | Šumadija (T) |
| 12.09.2021 16:00 | Polimlje | 0 : 2 | FAP | |
| 12.09.2021 16:00 | Sevojno | 3 : 2 | Parmenac | |
| 12.09.2021 16:00 | Zlatar | 1 : 0 | Jasen | |
| 12.09.2021 16:00 | Polet (T) | 2 : 2 | Polet (LJ) | |
| 12.09.2021 16:00 | Jedinstvo (K) | 0 : 2 | Sloboda | |
| 12.09.2021 11:00 | Jedinstvo Putevi | 1 : 0 | Prijevor | |
| 12.09.2021 16:00 | Savinac | 1 : 1 | Omladinac |
| 12.09.2021 16:00 | OFK Divci | 4 : 1 | Radnički (V) | |
| 12.09.2021 16:00 | Zadrugar | 0 : 2 | Drina | |
| 12.09.2021 16:00 | Borac | 0 : 1 | Mladost |
| 12.09.2021 16:00 | Sloga (B) | 3 : 0 | OFK Napredak | |
| 12.09.2021 16:00 | Mladi borac | 1 : 1 | Grizli ML | |
| 12.09.2021 16:00 | Đerdap | 0 : 2 | Sloboda | |
| 12.09.2021 16:00 | OFK Mihajlovac | 4 : 1 | Rudar 2001 | |
| 12.09.2021 16:00 | Sloga 33 | : | OFK Aranđelovac 1979 | |
| 12.09.2021 16:00 | Rudar (S) | 2 : 0 | Morava | |
| 12.09.2021 16:00 | Pomoravlje 1946 | : | Karađorđe |
| 12.09.2021 16:00 | Jedinstvo (GM) | 5 : 1 | Aluminjum | |
| 12.09.2021 16:00 | Mladost (B) | 2 : 0 | Bukovik | |
| 12.09.2021 16:00 | Rudar | 0 : 6 | OFK Sinđelić | |
| 12.09.2021 16:00 | Malošište | 2 : 1 | OFK Napredak 1929 | |
| 12.09.2021 16:00 | Orljane | 3 : 2 | Delijski Vis | |
| 12.09.2021 16:00 | Naša krila 1936 | 1 : 1 | Mladost (M) | |
| 12.09.2021 16:00 | Morava | 0 : 1 | Car Konstantin | |
| 12.09.2021 16:00 | Pukovac | 0 : 2 | OFK Niš |
| 12.09.2021 16:00 | Moravac Orion | 1 : 4 | Žitorađa | |
| 12.09.2021 16:00 | Čekmin | 4 : 0 | OFK Alakince | |
| 12.09.2021 16:00 | Plantaža | 0 : 2 | Jedinstvo | |
| 12.09.2021 16:00 | Jablanica | 1 : 0 | SFK Morava | |
| 12.09.2021 16:00 | Radan | 3 : 1 | Trnovac | |
| 12.09.2021 16:00 | Vranjska Banja | 0 : 2 | Nebeski Andjeli |
| 12.09.2021 16:00 | Župa | 3 : 0 | Jedinstvo (M) | |
| 12.09.2021 16:00 | Levač | 2 : 0 | Sloga (M) | |
| 12.09.2021 16:00 | OFK Lugomir | 2 : 1 | Blagotin | |
| 12.09.2021 16:00 | Gradina | 1 : 3 | Morava 1918 |
| 12.09.2021 11:00 | Jedinstvo (P) | 1 : 1 | OFK Slatina | |
| 12.09.2021 13:00 | Sloga | 1 : 4 | Lužnica |
| 12.09.2021 16:00 | Naša Zvezda | 7 : 0 | Radnički (S) | |
| 12.09.2021 16:00 | Kordun | 0 : 2 | Bratstvo 2019 | |
| 12.09.2021 16:00 | Budućnost (P) | 4 : 1 | Budućnost (M) | |
| 12.09.2021 16:00 | Budućnost (G) | 1 : 3 | ŽAK | |
| 12.09.2021 16:00 | Rusin | 4 : 2 | Vojvodina | |
| 12.09.2021 16:00 | Borac 46 | 4 : 3 | Crvenka |
| 12.09.2021 16:30 | Jedinstvo | 1 : 2 | Bačka 1923 | |
| 12.09.2021 16:30 | Petrovaradin | 1 : 1 | Crvena Zvezda | |
| 12.09.2021 16:30 | Tatra | 5 : 0 | ŽSK |
| 12.09.2021 16:00 | Vulturul | 1 : 1 | Partizan (G) | |
| 12.09.2021 16:00 | Crvena zvezda | 5 : 0 | Strela | |
| 12.09.2021 16:00 | Dolina | 4 : 1 | Partizan (U) | |
| 12.09.2021 16:00 | Dolovo | 0 : 3 | Jedinstvo Stević | |
| 12.09.2021 16:00 | Budućnost (A) | 5 : 0 | Spartak 1911 | |
| 12.09.2021 16:00 | Stari Tamiš | 0 : 2 | Potporanj | |
| 12.09.2021 16:00 | Sloga (BNS) | 0 : 0 | Hajdučica |
| 12.09.2021 16:00 | Fruškogorac | 3 : 1 | Borac (M) | |
| 12.09.2021 16:00 | Radnički | 1 : 5 | GFK Sloven | |
| 12.09.2021 16:00 | Sloga | 3 : 0 | Ljukovo | |
| 12.09.2021 16:00 | Napredak | 2 : 3 | Podrinje | |
| 12.09.2021 16:00 | Sremac (V) | 0 : 5 | Jadran | |
| 12.09.2021 16:00 | Sremac (Deč) | 0 : 2 | Hajduk |
| 12.09.2021 16:00 | Iskra | 1 : 1 | Sutjeska | |
| 12.09.2021 16:00 | Đurđin | 3 : 3 | Jadran | |
| 12.09.2021 16:00 | Bačka | 0 : 4 | Obilić (Z) |
| 12.09.2021 16:00 | Bačinac | 2 : 2 | Mladost 1948 | |
| 12.09.2021 16:00 | Jedinstvo | 0 : 3 | Železničar Kusadak | |
| 12.09.2021 16:00 | Mladi radnik 1940 | 2 : 0 | SASK | |
| 12.09.2021 16:00 | Polet | 2 : 1 | Radnik | |
| 12.09.2021 16:00 | Borac 1932 | 3 : 1 | Glavaš |
| 12.09.2021 16:30 | Mladi rudar 1954 | 0 : 1 | Banja 1957 | |
| 12.09.2021 16:30 | Marjan | 0 : 3 | Omladinac (D.R.) | |
| 12.09.2021 16:30 | Sloga (M) | 6 : 0 | Jasenica | |
| 12.09.2021 16:30 | Sloga (Z) | 1 : 2 | Prvi srpski ustanak | |
| 12.09.2021 16:30 | Vinča | 3 : 1 | Trnava | |
| 12.09.2021 16:30 | Plaskovac | 3 : 0 | ŽSK | |
| 12.09.2021 16:30 | Badnjevac | 1 : 4 | Lokomotiva | |
| 12.09.2021 16:30 | BSK | 0 : 2 | Šumadinac 1913 |
| 12.09.2021 16:00 | Brestovac | 3 : 1 | Rudna Glava | |
| 12.09.2021 11:00 | Ključ | 3 : 1 | Nemetali | |
| 12.09.2021 16:00 | Polom | 3 : 2 | Urovica | |
| 12.09.2021 16:00 | Polet | 2 : 0 | Poreč | |
| 12.09.2021 16:00 | Blizna | 3 : 2 | Mala Vrbica | |
| 12.09.2021 11:00 | Miloševo | 0 : 1 | Radnički (K) |
| 12.09.2021 16:30 | Umac | 4 : 2 | Polet | |
| 12.09.2021 16:30 | OFK Brza | 3 : 0 | Progres | |
| 12.09.2021 16:30 | Kumarevo 65 | 0 : 1 | Vučje | |
| 12.09.2021 16:30 | Zloćudovo | 4 : 3 | Mladost |
| 12.09.2021 16:30 | Mladost 1959 | 3 : 1 | BSK | |
| 12.09.2021 16:30 | Mladi borac | 4 : 2 | OFK Morava | |
| 12.09.2021 16:30 | Sloga | 3 : 2 | Bobište | |
| 12.09.2021 16:30 | Moravac | 3 : 0 | Real | |
| 12.09.2021 16:30 | Železničar | 2 : 1 | Jedinstvo (B) | |
| 12.09.2021 16:30 | Sloboda | 2 : 1 | Veliko Trnjane |
| 12.09.2021 16:00 | Pobeda | 4 : 1 | Polet | |
| 12.09.2021 16:00 | Jastrebac | 1 : 0 | Taskovići | |
| 12.09.2021 16:00 | Doljevac | 1 : 2 | Svrljig | |
| 12.09.2021 16:00 | Rad | 1 : 1 | Radnički 1947 | |
| 12.09.2021 16:00 | Moravac | 1 : 0 | Baličevac | |
| 12.09.2021 16:00 | Zemljoradnik | 7 : 0 | Toplica |
| 12.09.2021 16:30 | Osnić | 0 : 1 | Trebič | |
| 12.09.2021 16:30 | Graničar | : | Kosovo | |
| 12.09.2021 16:30 | Rudar (P) | 1 : 2 | Midžor | |
| 12.09.2021 16:30 | OFK Rtanj | 5 : 0 | Šljivar | |
| 12.09.2021 16:30 | Omladinac | 3 : 1 | Rudar Vrška Čuka | |
| 12.09.2021 16:30 | FSU Kraljevica | 1 : 3 | Rtanj | |
| 12.09.2021 16:30 | Radnički 1946 | 8 : 0 | Velika Jasikova |
| 12.09.2021 16:00 | Vinogradar | 2 : 0 | Parunovac | |
| 12.09.2021 16:00 | Mačkovac | 1 : 1 | Rubin | |
| 12.09.2021 16:00 | Kupci | 5 : 1 | Čitluk | |
| 12.09.2021 16:00 | Bošnjane | 2 : 2 | Sloga (Ć) | |
| 12.09.2021 16:00 | Sloga (L) | 4 : 0 | Sebečevac | |
| 12.09.2021 16:00 | FUD | 3 : 1 | 13. April |
| 12.09.2021 16:30 | Mladost (L) | 3 : 2 | Vojvodina (NM) | |
| 12.09.2021 16:30 | Mladost (BD) | 5 : 0 | Radnički | |
| 12.09.2021 16:30 | Rusanda | 1 : 2 | ASK | |
| 12.09.2021 16:30 | Vojvodina (B) | 4 : 1 | Delija | |
| 12.09.2021 16:30 | ŽFK Banat | 3 : 1 | Borac | |
| 12.09.2021 16:30 | ŽAK | 3 : 2 | Budućnost |
| 12.09.2021 16:00 | Kolare | 2 : 0 | Dragocvet | |
| 12.09.2021 16:00 | Sloga | 3 : 2 | Juhor (G) | |
| 12.09.2021 16:00 | Morava | 5 : 2 | Javor | |
| 12.09.2021 16:00 | OFK Juhor 2016 | 1 : 0 | Partizan (G) | |
| 12.09.2021 16:00 | GFK Tabane | 1 : 3 | Budućnost (Đ) | |
| 12.09.2021 16:00 | Napredak | 2 : 1 | Budućnost (M) |
| 12.09.2021 16:30 | Napredak 1936 | 1 : 0 | Sloga (L) | |
| 12.09.2021 16:30 | Šapine | 4 : 1 | Žitkovica 2017 | |
| 12.09.2021 16:30 | Rudar (Kr) | 6 : 2 | Sirakovo | |
| 12.09.2021 16:30 | Krilaš | 0 : 1 | Borac (K) | |
| 12.09.2021 16:30 | Borac (Ž) | 1 : 2 | Obilić | |
| 12.09.2021 16:30 | Železničar | 2 : 1 | Vihor | |
| 12.09.2021 16:30 | Mladost (R) | 0 : 1 | Zvižd |
| 12.09.2021 16:00 | Željuša | 2 : 3 | Zadrugar | |
| 12.09.2021 16:00 | Dragoš | 1 : 2 | Pobeda |
| 12.09.2021 16:00 | Mladost | 5 : 4 | Budućnost (Z) | |
| 12.09.2021 16:00 | Beljina | 1 : 0 | Turbina | |
| 12.09.2021 16:00 | Krtinska | 2 : 3 | Barajevo | |
| 12.09.2021 16:00 | OFK Budućnost | 4 : 1 | Šumadija | |
| 12.09.2021 18:00 | BSK 1926 | 1 : 1 | Strelac | |
| 12.09.2021 16:00 | Omladinac | 5 : 0 | Lisović 1977 |
| 12.09.2021 16:00 | Napredak | 0 : 1 | SUF Dubona | |
| 12.09.2021 16:00 | Rabrovac | 1 : 6 | Kaluđerica 1969 | |
| 12.09.2021 16:00 | Podunavac | 0 : 0 | Pudarci | |
| 12.09.2021 16:00 | Šumadija 1962 | 2 : 0 | Vrčin | |
| 12.09.2021 16:00 | Velika Krsna | 3 : 0 | Zaklopača | |
| 12.09.2021 16:00 | Dunavac | 2 : 0 | SUF Kovačevac 1956 | |
| 12.09.2021 16:00 | Đurinci | 1 : 1 | Boleč |
| 12.09.2021 16:00 | Dunav | 3 : 3 | Šećeranac Ada | |
| 12.09.2021 16:00 | Umka | 1 : 2 | PKB Kovilovo | |
| 12.09.2021 16:00 | Beograd Karaburma | 0 : 1 | Milutinac | |
| 12.09.2021 16:00 | Heroj Polet | 0 : 3 | Balkan Mirijevo | |
| 12.09.2021 11:00 | Hajduk | 4 : 0 | Srem |
| 12.09.2021 16:00 | Jedinstvo | 2 : 3 | Kolonija | |
| 12.09.2021 16:00 | Srbija | 1 : 1 | Sloga (D) | |
| 12.09.2021 16:00 | Mladost (P) | 0 : 2 | Košutnjak | |
| 12.09.2021 16:00 | Šumadinac | 5 : 2 | Zastava | |
| 12.09.2021 16:00 | Pobeda 1926 | 2 : 2 | Kutlovo |
| 12.09.2021 16:30 | ZSK | 0 : 5 | OFK Brđanac | |
| 12.09.2021 16:30 | Trlić | 2 : 1 | Iskra | |
| 12.09.2021 16:30 | OFK Senjak | 1 : 1 | Žabari | |
| 12.09.2021 11:00 | Toplica | 1 : 5 | OFK Osečina | |
| 12.09.2021 16:30 | Dimitrije Tucović | 3 : 0 | Banjani | |
| 12.09.2021 16:30 | Mladost (D) | 1 : 0 | Spartak 1924 |
| 12.09.2021 16:00 | Proleter | 3 : 1 | Mladost | |
| 12.09.2021 16:00 | Planinac 1933 | 3 : 1 | Čegar 2013 | |
| 12.09.2021 16:00 | Radnički 1936 | 4 : 0 | Crvena zastava | |
| 12.09.2021 16:00 | Vulkan 1963 | 3 : 2 | Stevan Nešticki | |
| 12.09.2021 16:00 | Morava | 3 : 0 | Sloboda | |
| 12.09.2021 16:00 | Palilulac | 1 : 0 | Čegar 1946 |
| 12.09.2021 16:30 | Dragačevo | 1 : 1 | Gorušica | |
| 12.09.2021 16:30 | Prilike | 3 : 0 | Voćar | |
| 12.09.2021 16:30 | Morava | 2 : 2 | Kej |
| 12.09.2021 16:30 | Orlovac 1932 | 4 : 0 | Donja Vrbava | |
| 12.09.2021 16:30 | Zadrugar | 2 : 3 | Rudar | |
| 12.09.2021 16:30 | Jedinstvo (GG) | 0 : 4 | Napredak | |
| 12.09.2021 16:30 | Šumadija | 0 : 0 | Mladost |
| 12.09.2021 16:30 | Radnik | 0 : 1 | Tavnik | |
| 12.09.2021 16:30 | Ribnica | 1 : 0 | OFK Ras | |
| 12.09.2021 16:30 | OFK Progorelica | 2 : 1 | Mladost (V) | |
| 12.09.2021 16:30 | Zvezda | 4 : 1 | Mataruge | |
| 12.09.2021 16:30 | Omladinac (NS) | 0 : 2 | Napredak | |
| 12.09.2021 11:00 | Proleter | 2 : 0 | Jedinstvo 2017 | |
| 12.09.2021 16:30 | Novi Pazar 1928 | 0 : 1 | Ibar |
| 12.09.2021 16:00 | Jedinstvo (MZ) | 2 : 0 | Karađorđe | |
| 12.09.2021 16:00 | Gučevo 1929 | 2 : 3 | Majur | |
| 12.09.2021 16:00 | Drina | 3 : 1 | Lipolist | |
| 12.09.2021 16:00 | Cer | 1 : 0 | Podrinje | |
| 12.09.2021 16:00 | Hajduk Stanko | 1 : 0 | Radnički (Ko) | |
| 12.09.2021 16:00 | Rudar | 2 : 0 | Milan Orlić | |
| 12.09.2021 16:00 | Sloga | 4 : 0 | Vidojevica | |
| 12.09.2021 16:00 | Jedinstvo (Š) | 1 : 2 | Radnički (Kl) |
| 12.09.2021 | OFK Kotroman | 0 : 2 | Avijatičar Vranjani | |
| 12.09.2021 | Sečica | 1 : 6 | Ježevica | |
| 12.09.2021 | Omladinac | 3 : 2 | Polet | |
| 12.09.2021 | Plavi Tok | 2 : 2 | Jedinstvo |
| 12.09.2021 16:00 | Lazarica | 6 : 0 | Prvi partizan | |
| 12.09.2021 | Perućac | 3 : 1 | Tara | |
| 12.09.2021 | Čajetina | 0 : 0 | Višesava | |
| 12.09.2021 | Rampa | 3 : 1 | Sloga |
| 12.09.2021 11:00 | Dračić 2018 | 3 : 2 | Omladinac | |
| 12.09.2021 11:00 | Stari drugari | 5 : 0 | OFK Povlen | |
| 12.09.2021 11:00 | Lukavac | 0 : 4 | Polet | |
| 12.09.2021 11:00 | Jadar 2013 | 3 : 1 | Tešnjar | |
| 12.09.2021 11:00 | Milenko Pavlović | 4 : 1 | Kolubara 2 | |
| 12.09.2021 11:00 | Mali korak | 2 : 1 | Junior Novo Naselje | |
| 12.09.2021 11:00 | Popadić | 0 : 1 | Kotešica | |
| 12.09.2021 11:00 | Rakac Stave | 0 : 1 | Rajac |
| 12.09.2021 16:00 | Graničar | 3 : 2 | Omladinac (B) | |
| 12.09.2021 16:00 | Zadrugar | 2 : 7 | OFK Odžaci | |
| 12.09.2021 16:00 | BSK | 4 : 0 | Dinamo 1923 | |
| 12.09.2021 16:00 | Hajduk | 2 : 3 | Kula | |
| 12.09.2021 16:00 | Mladost | 1 : 1 | Terekveš | |
| 12.09.2021 16:00 | Polet | 2 : 1 | Omladinac (D) | |
| 12.09.2021 16:00 | Aleksa Šantić | 4 : 1 | Dunav |
| 12.09.2021 16:00 | Donji Kopaonik | 4 : 2 | Župski biseri | |
| 12.09.2021 13:00 | Omladinac | 1 : 0 | Vinogradar | |
| 12.09.2021 16:00 | Kamenorezac 76 | 1 : 0 | Mladost |
| 12.09.2021 16:00 | Glogonj | 1 : 0 | Radnički (B) | |
| 12.09.2021 16:00 | BSK Bavanište | 2 : 1 | Pobeda | |
| 12.09.2021 16:00 | Omladinac (D) | 4 : 2 | Mundial | |
| 12.09.2021 16:00 | Omladinac 1927 | 3 : 3 | Unirea |
| 12.09.2021 16:30 | Šarbane | 0 : 1 | Pepeljevac | |
| 12.09.2021 16:30 | Mladost (V) | 0 : 0 | Polet (DL) | |
| 12.09.2021 16:30 | Joševa | 2 : 3 | Pambukovica | |
| 12.09.2021 16:30 | Čučuge | 3 : 1 | Polet (T) | |
| 12.09.2021 16:30 | OFK Paljuvi | 3 : 1 | Nepričava | |
| 12.09.2021 16:30 | Tvrdojevac | 3 : 2 | Jedinstvo (M) | |
| 12.09.2021 16:30 | Ratkovac | 0 : 0 | Sovljak |
| 12.09.2021 16:30 | PSK Putinci | 1 : 5 | Krušedol | |
| 12.09.2021 16:30 | Graničar (O) | 3 : 1 | Rudar | |
| 12.09.2021 16:30 | Jedinstvo | 0 : 0 | Polet | |
| 12.09.2021 16:00 | Fruškogorac | 0 : 2 | Srem | |
| 12.09.2021 16:30 | Graničar (G) | 0 : 6 | Mladost | |
| 12.09.2021 16:30 | Napredak | 6 : 1 | ČSK Čortanovci | |
| 12.09.2021 16:30 | Hajduk 1932 | 0 : 4 | Šumar |
| 12.09.2021 16:00 | Potisje | 2 : 2 | Zadrugar | |
| 12.09.2021 16:00 | Partizan | 2 : 3 | Bilećanin | |
| 12.09.2021 16:00 | Lehel | 2 : 2 | Tamiš | |
| 12.09.2021 16:00 | Mladost | 5 : 2 | Tisa 1933 | |
| 12.09.2021 16:00 | MSK | 0 : 3 | OFK Stajićevo | |
| 12.09.2021 16:00 | Naftagas | 1 : 5 | OFK Gradnulica | |
| 12.09.2021 16:00 | Radnički 1911 | 2 : 0 | OFK Klek |
| 12.09.2021 11:00 | Gradac | 3 : 0 | Radnik Sušica | |
| 12.09.2021 11:00 | Badince | 0 : 2 | Radnički (P) |
| 12.09.2021 16:00 | Sloga | 3 : 2 | Luk | |
| 12.09.2021 16:00 | TE Gučevo | 2 : 2 | Jadar 1961 | |
| 12.09.2021 16:00 | Antimon | 4 : 2 | 7. Juli | |
| 12.09.2021 16:00 | Velika Reka | 2 : 1 | Mladost (DB) | |
| 12.09.2021 16:00 | Jedinstvo | 2 : 1 | Studenac | |
| 12.09.2021 16:00 | Jelav | 0 : 1 | Prva Iskra |
| 12.09.2021 16:30 | Partizan | 1 : 3 | Skela | |
| 12.09.2021 16:30 | Posavina | 1 : 1 | Borac | |
| 12.09.2021 16:30 | Jedinstvo | 1 : 2 | Polet | |
| 12.09.2021 16:30 | Munja | 0 : 4 | OFK Zabrežje | |
| 12.09.2021 16:30 | Duboko | 0 : 2 | Rvati |
| 12.09.2021 16:30 | Omladinac | 1 : 0 | Radnički | |
| 12.09.2021 16:30 | Mladi radnik | 1 : 3 | OFK Batinac | |
| 12.09.2021 16:30 | Rudar | 1 : 1 | Donja Mutnica | |
| 12.09.2021 16:30 | Mladost | 3 : 4 | 15. Avgust 1950 | |
| 12.09.2021 16:30 | Sloga | 0 : 2 | Sinđelić | |
| 12.09.2021 16:30 | Pomoravlje | 6 : 2 | Planinac |
| 12.09.2021 16:00 | Busije | 0 : 2 | Novi Beograd | |
| 12.09.2021 16:00 | Velika Moštanica | 2 : 0 | Borac | |
| 12.09.2021 16:00 | BUSK | 0 : 2 | Železnik 1930 | |
| 12.09.2021 11:00 | 13. maj | 1 : 2 | Rekreativo 011 | |
| 12.09.2021 16:00 | Šumadinac | 2 : 0 | Miljakovac | |
| 12.09.2021 10:00 | Bežanija | 1 : 1 | Zmaj Novi grad |
| 12.09.2021 16:00 | Bratstvo | 1 : 2 | OFK Crvenka | |
| 12.09.2021 16:00 | Lepušnica | 2 : 1 | Resnik | |
| 12.09.2021 16:00 | Pionir | 2 : 1 | OFK Lug 2020 | |
| 12.09.2021 16:00 | Avala 1939 | 3 : 0 | Mladi proleter | |
| 12.09.2021 16:00 | Minel | 3 : 0 | Sveti Stefan |
| 12.09.2021 11:00 | Seljak | 0 : 1 | Jadran | |
| 12.09.2021 16:00 | 21. oktobar | 8 : 2 | Dobrača | |
| 12.09.2021 11:00 | Kragujevac | 6 : 4 | Ćava | |
| 12.09.2021 16:00 | OFK Bagremar | 1 : 3 | OFK Žeželj |
| 12.09.2021 16:30 | Partizan | 0 : 1 | Feniks | |
| 12.09.2021 16:30 | BSK | 6 : 1 | Mladost (P) | |
| 12.09.2021 16:30 | Sloga | 1 : 0 | Borac | |
| 12.09.2021 16:30 | Šumadija | 3 : 1 | Karađorđe |
| 12.09.2021 16:30 | Morava | 0 : 1 | GFK Strelište | |
| 12.09.2021 16:30 | Mladost (K) | 1 : 0 | Šantarovac | |
| 12.09.2021 16:30 | Sinđelić 1934 | 2 : 6 | Kupinovac | |
| 12.09.2021 16:30 | Mladost (G) | 2 : 0 | Bratstvo | |
| 12.09.2021 16:30 | Vinorača | 2 : 1 | Vinogradar | |
| 12.09.2021 16:30 | Trnava | 7 : 0 | Šumadinac | |
| 12.09.2021 16:30 | Osaonica | 1 : 1 | Mladost (T) |
| 12.09.2021 16:30 | Mladost (J) | 2 : 1 | Borac | |
| 12.09.2021 16:30 | Šumadinac | 4 : 1 | Kopljari | |
| 12.09.2021 16:30 | Šamot | 2 : 2 | Kalipolje | |
| 12.09.2021 11:00 | Trešnjevica | 0 : 0 | Mladost (R) | |
| 12.09.2021 16:30 | Venčani | 5 : 1 | B 2000 | |
| 12.09.2021 11:00 | Gorski Car | 5 : 1 | Tulež |
| 12.09.2021 16:30 | Slavija (P) | 2 : 0 | Orlovi | |
| 12.09.2021 16:30 | Bački Hajduk | 0 : 1 | Tvrđava | |
| 12.09.2021 16:30 | Kulpin | 11 : 3 | Borac | |
| 12.09.2021 16:30 | Bačka (D) | 8 : 0 | Slavija (B) | |
| 12.09.2021 16:30 | Mladost | 1 : 3 | Neštin | |
| 12.09.2021 16:30 | Maglić | 7 : 0 | Krivanj |
| 12.09.2021 16:00 | Budućnost (PD) | 1 : 0 | Mladost | |
| 12.09.2021 16:00 | Duško | 2 : 1 | Sloboda | |
| 12.09.2021 16:00 | Petlovača | 2 : 1 | Stojan Lazarac | |
| 12.09.2021 16:00 | Gorki | 2 : 1 | Sloga | |
| 12.09.2021 16:00 | Budućnost (Z) | 1 : 1 | Torpedo | |
| 12.09.2021 16:00 | Mladi borac | 2 : 1 | Napredak |
| 12.09.2021 16:30 | Gruža | 4 : 1 | Apolon 2018 | |
| 12.09.2021 11:00 | Studen Vitez | 0 : 4 | Omladinac | |
| 12.09.2021 16:30 | Lazac | 4 : 1 | Mineral 2015 | |
| 12.09.2021 11:00 | Miločajac | 4 : 3 | Jedinstvo (G) | |
| 12.09.2021 16:30 | Kraljevo Hajduk | 2 : 2 | Borac | |
| 12.09.2021 16:30 | Jovo Kursula | 2 : 2 | Braća Vuković | |
| 12.09.2021 16:30 | Popovići Vrnjci | 3 : 1 | Jedinstvo (D) |
| 12.09.2021 16:00 | Sloga (K) | 1 : 2 | Vlašić | |
| 12.09.2021 16:00 | Dobrava | 2 : 2 | Mladost (PP) | |
| 12.09.2021 16:00 | OFK Letnjikovac 1983 | 0 : 1 | Šipurske livade | |
| 12.09.2021 16:00 | Sloga (M) | 0 : 3 | Trešnjevka | |
| 12.09.2021 16:00 | Pričinović | 1 : 1 | Dobrava Žabar 2020 |
| 12.09.2021 16:00 | Novoselac | 8 : 0 | Jasenovik 2018 | |
| 12.09.2021 16:00 | Supovac | 3 : 0 | Sloga (DT) | |
| 12.09.2021 16:00 | Sloga 1948 | 4 : 1 | Spartak | |
| 12.09.2021 16:00 | Mladost | 1 : 4 | Standard 2021 | |
| 12.09.2021 16:00 | Vrtište | 1 : 6 | Mramor | |
| 12.09.2021 16:00 | Mezgraja | 2 : 2 | Real Niš |
| 12.09.2021 16:30 | 1. Oktobar | 1 : 2 | Terekveš | |
| 12.09.2021 16:30 | Napredak | 1 : 4 | Jedinstvo (NB) | |
| 12.09.2021 16:30 | 2. Oktobar | 7 : 0 | SU Podgrmeč | |
| 12.09.2021 16:30 | Proleter | 5 : 2 | Roham |
| 12.09.2021 16:30 | Barič | 0 : 0 | Sloga 1932 | |
| 12.09.2021 16:30 | Napredak (B) | 3 : 0 | Ljubičevo | |
| 12.09.2021 16:30 | Stig 1955 | 3 : 2 | Batovac | |
| 12.09.2021 16:30 | Dizel | 3 : 0 | OFK Braničevo | |
| 12.09.2021 16:30 | Mladi Borac | 3 : 2 | Beli Orao | |
| 12.09.2021 16:30 | Napredak 1934 | 2 : 3 | BSK 1931 |
| 12.09.2021 16:30 | Manastirica | 0 : 0 | Soko | |
| 12.09.2021 16:30 | Zadrugar 1947 | 4 : 1 | Pobeda 1953 | |
| 12.09.2021 16:30 | Mlava (ML) | 5 : 1 | Sloga 1945 | |
| 12.09.2021 16:30 | Integral | 5 : 0 | Bata Bulić | |
| 12.09.2021 16:30 | Jedinstvo (S) | 0 : 3 | Napredak (S) | |
| 12.09.2021 16:30 | Rade Milošević | 3 : 0 | Mladost (K) |
| 12.09.2021 11:00 | Mladost (PR) | 3 : 0 | Borac | |
| 12.09.2021 16:00 | Temac | 4 : 0 | Mladost (MS) | |
| 12.09.2021 16:00 | Veliki Suvodol | 2 : 0 | Lokomotiva |
| 12.09.2021 16:00 | Sloga | 8 : 1 | Tempo | |
| 12.09.2021 11:00 | Jedinstvo | 2 : 0 | Napredak 2012 | |
| 12.09.2021 11:00 | Rutevac | 2 : 1 | Borac | |
| 12.09.2021 11:00 | Rudar 2016 | 1 : 1 | Crvena zvezda |
| 12.09.2021 16:00 | Badljevica | 3 : 2 | Vožd 2020 | |
| 12.09.2021 16:00 | Landol | 0 : 4 | Crvena zvezda | |
| 12.09.2021 16:00 | Proleter 1947 | 3 : 0 | Skobalj | |
| 12.09.2021 16:00 | Lunjevac | 3 : 1 | Stari Hrast 2018 | |
| 12.09.2021 16:00 | Godomin | 1 : 1 | Jezava | |
| 12.09.2021 16:00 | Budućnost | 8 : 0 | Omladinac |
| 12.09.2021 17:00 | Brezova | 4 : 0 | Gradina | |
| 12.09.2021 17:00 | Radnički | 4 : 3 | Devići | |
| 12.09.2021 17:00 | Bratstvo | 2 : 1 | Sloga |
| 12.09.2021 16:00 | Tromeđa | 2 : 1 | Graničar | |
| 12.09.2021 16:00 | Jedinstvo (M) | 1 : 0 | Slavija | |
| 12.09.2021 16:00 | Hajduk | 0 : 4 | Jedinstvo (SK) | |
| 12.09.2021 16:00 | Čoka | 0 : 7 | Tisa | |
| 12.09.2021 16:00 | Šampion | 1 : 3 | Potisje |
| 12.09.2021 16:00 | Erdevik 2017 | 4 : 2 | Srem | |
| 12.09.2021 16:00 | Obilić 1993 | 0 : 0 | Hajduk | |
| 12.09.2021 16:00 | Zmaj | 5 : 4 | OFK Bikić | |
| 12.09.2021 16:00 | Fruška Gora | 2 : 3 | BSK | |
| 12.09.2021 16:00 | OFK Zeka Buljubaša | 3 : 0 | Graničar (A) | |
| 12.09.2021 16:00 | Jedinstvo | 4 : 1 | Graničar (K) |
| 12.09.2021 16:00 | FC Stella Rossa | 1 : 1 | Backovac Junajted | |
| 12.09.2021 16:00 | Omladinac | 1 : 7 | Velereč 94 | |
| 12.09.2021 16:00 | Ozremica | 2 : 1 | Majdan | |
| 12.09.2021 16:00 | Jablanica | 3 : 0 | Semedraž | |
| 12.09.2021 16:00 | Takovski Ustanak | 1 : 4 | Šilopaj |
| 12.09.2021 16:30 | OFK Mala Bosna 2015 | 3 : 0 | Hajduk 1950 | |
| 12.09.2021 16:30 | Čantavir | 3 : 2 | Palić | |
| 12.09.2021 16:30 | Elektrovojvodina | 3 : 0 | Bikovo | |
| 12.09.2021 16:30 | Žednik | 4 : 1 | Lokomotiva | |
| 12.09.2021 16:30 | Solid | 1 : 1 | Vinogradar |
| 12.09.2021 16:00 | Banat (D) | 7 : 1 | Polet | |
| 12.09.2021 16:00 | Ševac | 2 : 3 | Karaš (J) | |
| 12.09.2021 16:00 | Ratar | 1 : 2 | Partizan | |
| 12.09.2021 16:00 | Borac (VS) | 4 : 3 | Dunav | |
| 12.09.2021 16:00 | Vitorul | 0 : 1 | Omladinac | |
| 12.09.2021 16:00 | Karaš (K) | 3 : 1 | Banat (I) |
| 12.09.2021 16:30 | Slemen | 5 : 1 | Palilulac | |
| 12.09.2021 16:30 | Jedinstvo | 4 : 2 | Sloboda 2013 |
| 12.09.2021 16:00 | Tomislavci | 6 : 0 | Pobeda | |
| 12.09.2021 16:00 | Jedinstvo | 1 : 4 | Proleter |
| 12.09.2021 16:30 | Bačka | 1 : 0 | Obilić | |
| 12.09.2021 16:30 | Čenej | 0 : 2 | Hajduk (G) | |
| 12.09.2021 16:30 | Vinogradar | 6 : 0 | Titel | |
| 12.09.2021 16:30 | Sloga | 1 : 0 | Železničar | |
| 12.09.2021 16:30 | Borac | 3 : 2 | Hajduk (Č) | |
| 12.09.2021 10:00 | Moskva | 0 : 11 | OFK Sirig | |
| 12.09.2021 16:30 | OFK Hajduk | 3 : 2 | Susek |
| 12.09.2021 16:00 | Lovac | 2 : 2 | Vitez | |
| 12.09.2021 16:00 | Kameni | 5 : 1 | Mladost 1935 | |
| 12.09.2021 16:00 | OFK Brestač | 2 : 5 | Kupinovo |
| 12.09.2021 16:00 | Sloga | 2 : 4 | Jedinstvo 2014 | |
| 12.09.2021 16:00 | Borac | 3 : 0 | Zlatica | |
| 12.09.2021 16:00 | KSK Konak 1926 | 1 : 6 | Proleter |
| 12.09.2021 16:30 | Ljubinić | 5 : 0 | Sloga | |
| 12.09.2021 16:30 | Belo Polje | 9 : 3 | Crvena zastava | |
| 12.09.2021 16:30 | OFK Urovci | 7 : 0 | Proleter |
| 12.09.2021 11:00 | Sparta | 0 : 2 | Provo 2015 | |
| 12.09.2021 16:00 | Hajduk | 1 : 1 | Polet | |
| 12.09.2021 11:00 | Petrovac 74 | 4 : 0 | Torpedo | |
| 12.09.2021 16:00 | Mladost (Z) | 1 : 5 | Jedinstvo 2014 | |
| 12.09.2021 11:00 | Skupljen 2013 | 0 : 7 | Bobovik | |
| 12.09.2021 16:00 | Verko | 3 : 1 | Belpos |
| 12.09.2021 16:00 | Hajduk 1936 | 2 : 0 | Jovanovac | |
| 12.09.2021 16:00 | Šumadija | 3 : 0 | Apolon 4 | |
| 12.09.2021 16:00 | Bukorovac | 0 : 0 | Borba | |
| 12.09.2021 16:00 | Azbest | 2 : 0 | Kremenac |
| 12.09.2021 16:30 | Stubal | 3 : 1 | Mladost 1981 | |
| 12.09.2021 16:30 | Sloga Obrva | 5 : 1 | Zgodačica | |
| 12.09.2021 16:30 | Morava (S) | 2 : 4 | Mladost 1925 |
| 12.09.2021 11:00 | Stara Čaršija | 5 : 0 | BSK 2014 | |
| 12.09.2021 11:00 | Biljanovac | 6 : 3 | Borac (A) | |
| 12.09.2021 16:30 | Magnohrom | 0 : 0 | Mladi radnik 1925 |
| 12.09.2021 11:00 | Borjak 2013 | 1 : 1 | Omladinac (V) | |
| 12.09.2021 11:00 | Velika Morava | 1 : 3 | Mladost 1977 | |
| 12.09.2021 21:00 | Parcane | 2 : 4 | OFK Orašje 1960 | |
| 12.09.2021 11:00 | Obilić | 1 : 5 | Šampion 2013 |
| 12.09.2021 | Hrtkovci | 4 : 0 | Jedinstvo | |
| 12.09.2021 | Polet | 2 : 1 | Fruškogorac | |
| 12.09.2021 00:00 | Borac | 2 : 1 | Donji Petrovci |
| 12.09.2021 | Vojvodina | 7 : 1 | Sloga (K) | |
| 12.09.2021 | 27. Oktobar | 0 : 2 | Sloga (M) | |
| 12.09.2021 | Car Uroš | 1 : 0 | Dunav | |
| 12.09.2021 | Borac | 2 : 2 | Planinac |
| 12.09.2021 16:00 | Polet | 2 : 0 | Dinamo | |
| 12.09.2021 16:00 | Jedinstvo (R) | 0 : 1 | PIK | |
| 12.09.2021 16:00 | Jedinstvo Lemeš | 4 : 0 | Sport |
| 12.09.2021 16:00 | OFK Dragoševac | 1 : 1 | Dražmirovac | |
| 12.09.2021 16:00 | Mladost | 2 : 0 | Napredak | |
| 12.09.2021 16:00 | Dobra Voda | 4 : 0 | Domaćin | |
| 12.09.2021 16:00 | Mladi radnik | 6 : 0 | Belica | |
| 12.09.2021 16:00 | Omladinac | 1 : 3 | Jedinstvo | |
| 12.09.2021 16:00 | Kolonija | 0 : 4 | Sloboda |
| 12.09.2021 11:00 | Strelac 001 | 0 : 2 | Dokmir | |
| 12.09.2021 11:00 | Tulari | 0 : 4 | Brezovica | |
| 12.09.2021 11:00 | OFK Takovo | 0 : 4 | Gunjevac | |
| 12.09.2021 11:00 | Budućnost 1995 | 0 : 1 | Vrelo | |
| 12.09.2021 11:00 | Vukona | 5 : 1 | Zvizdar 2012 |
| 12.09.2021 | Jedinstvo (lj) | 4 : 3 | Bratstvo | |
| 12.09.2021 | Borac | 0 : 2 | OFK Bingula | |
| 12.09.2021 | Jedinstvo (M) | 2 : 1 | Graničar | |
| 12.09.2021 | Jednota | 2 : 4 | Sinđelić | |
| 12.09.2021 | Napredak | 4 : 1 | Omladinac |
| 12.09.2021 16:00 | Železničar | 3 : 0 | Polet | |
| 12.09.2021 16:00 | ISK Izvor | 4 : 0 | Popovac | |
| 12.09.2021 16:00 | BSK | 0 : 4 | Istok 63 |
| 12.09.2021 16:00 | Sloboda | 1 : 0 | Hajduk | |
| 12.09.2021 16:00 | Budućnost | 1 : 3 | Razvitak | |
| 12.09.2021 10:00 | Potočac | 1 : 1 | Napredak (Sv) | |
| 12.09.2021 10:00 | Moravac | 3 : 3 | Heroj | |
| 12.09.2021 16:00 | Jedinstvo | 2 : 0 | Zemljoradnik |
| 12.09.2021 16:00 | Borac | 0 : 1 | Tempo | |
| 12.09.2021 16:00 | Kolonija | 3 : 1 | Jedinstvo |
| 12.09.2021 16:30 | Sloga | 1 : 2 | Sloboda |
| 12.09.2021 16:30 | Proleter | 2 : 3 | Strmovo | |
| 12.09.2021 16:30 | Mladost | 2 : 1 | Mladi radnik | |
| 12.09.2021 16:30 | 20. Oktobar | 5 : 2 | OFK Polet |
| 12.09.2021 16:00 | Mladost 1970 | : | Stiški Kurjak | |
| 12.09.2021 16:00 | Baštovan 2015 | 1 : 7 | Kumane | |
| 12.09.2021 16:00 | Dunavac 1929 | 2 : 2 | Polet | |
| 12.09.2021 16:00 | Borac 2016 | 5 : 0 | Pek | |
| 12.09.2021 16:00 | Žika Marković - Uča | 2 : 1 | Sloga TOP | |
| 12.09.2021 16:00 | Ram | 1 : 2 | Mirko Tomić |
| 12.09.2021 11:00 | OFK Stublenica | 4 : 2 | Kalenić | |
| 12.09.2021 11:00 | Sloga (V) | 0 : 3 | Kolubara (LP) | |
| 12.09.2021 11:00 | Murgaš 2012 | 2 : 2 | Trnjaci 2021 |
| 12.09.2021 11:00 | Gornje Sinkovce | 1 : 5 | Radnik 2013 | |
| 12.09.2021 11:00 | Morava | 1 : 0 | Moravac |
| 12.09.2021 10:00 | Zvezda | 1 : 1 | Mlava (R) | |
| 12.09.2021 10:00 | Budućnost (M) | 2 : 0 | Osanica | |
| 12.09.2021 10:00 | Borac (V) | 5 : 2 | Vukovac 98 |
| 12.09.2021 11:00 | Radnik | 2 : 2 | Napredak | |
| 12.09.2021 11:00 | BSK 1924 | 3 : 0 | Crni Vitez |
| 12.09.2021 16:00 | Vladimirovac | 1 : 3 | Mladost | |
| 12.09.2021 16:00 | Banatul | 2 : 1 | Janošik | |
| 12.09.2021 16:00 | Crvena zvezda | 0 : 2 | Dobrica |
| 12.09.2021 10:00 | Jarmenovci | 0 : 3 | Budućnost (B) | |
| 12.09.2021 10:00 | Maskar | 11 : 1 | Proleter 1922 | |
| 12.09.2021 10:00 | Gornja Trnava 1938 | 4 : 0 | Proleter 1936 | |
| 12.09.2021 10:00 | Krćevac 04 | 0 : 1 | Junkovac |
| 12.09.2021 16:30 | Sremac (J) | 0 : 3 | Borac (R) | |
| 12.09.2021 16:30 | Borac (VR) | 3 : 0 | Sloga (Z) | |
| 12.09.2021 16:30 | Mitros | 0 : 2 | OFK Bosut |
| 12.09.2021 16:30 | Planinac | 0 : 3 | Srem | |
| 12.09.2021 16:30 | Trgovački | 7 : 1 | Sloboda | |
| 12.09.2021 16:30 | Sparta | 1 : 0 | Napredak |
| 12.09.2021 11:00 | Culjković | 3 : 1 | OFK Jelen | |
| 12.09.2021 11:00 | Zadrugar Milkivit | 2 : 1 | Jedinstvo 2020 | |
| 12.09.2021 11:00 | POFK Letnjikovac | : | OFK Varna |
| 12.09.2021 11:00 | Bojić | 2 : 3 | Mladost Svileuva | |
| 12.09.2021 11:00 | Rankovac | 7 : 1 | Jedinstvo | |
| 12.09.2021 11:00 | Galeb | 3 : 2 | Rudar | |
| 12.09.2021 11:00 | Mladost Slatina | 2 : 4 | Sava | |
| 12.09.2021 11:00 | Metlić | 2 : 1 | Borac BTG | |
| 12.09.2021 11:00 | Mišar | 3 : 3 | Zablaće |
| 12.09.2021 11:00 | Udarnik 2015 | 0 : 1 | Vukan | |
| 12.09.2021 11:00 | Borac | 1 : 1 | Melnica |
| 12.09.2021 16:00 | Stolice | 2 : 1 | Jadar 07 | |
| 12.09.2021 16:00 | Hajduk | 6 : 1 | Borac | |
| 12.09.2021 16:00 | Mladost (G) | 2 : 1 | 14. Oktobar | |
| 12.09.2021 16:00 | Mladost (B) | 2 : 0 | Gradilište | |
| 12.09.2021 16:00 | Jadar | 0 : 3 | Paskovac | |
| 12.09.2021 16:00 | Sloga | 3 : 0 | Granit |
| 12.09.2021 16:30 | Rudar Prijedor | 3 : 0 | Posušje | |
| 12.09.2021 21:00 | Široki Brijeg | : | Željezničar |
| 12.09.2021 16:30 | Željezničar Sport Team | 0 : 1 | Sloga |
| 12.09.2021 17:00 | Arsenal | 2 : 1 | Mladost | |
| 12.09.2021 19:00 | Kom | : | OFK Titograd | |
| 12.09.2021 19:00 | Berane | : | Igalo | |
| 12.09.2021 17:00 | Cetinje | 0 : 2 | Bokelj | |
| 12.09.2021 17:00 | Grbalj | 0 : 3 | Jedinstvo |
| 12.09.2021 15:00 | Bordeaux | 2 : 3 | Lens | |
| 12.09.2021 15:00 | Brest | 1 : 1 | Angers | |
| 12.09.2021 20:45 | Olympique Lyonnais | 3 : 1 | Strasbourg | |
| 12.09.2021 15:00 | Metz | 0 : 2 | Troyes | |
| 12.09.2021 13:00 | Montpellier | 2 : 0 | Saint-Étienne | |
| 12.09.2021 17:00 | Nantes | 0 : 2 | Nice | |
| 12.09.2021 15:00 | Rennes | 0 : 2 | Reims |
| 12.09.2021 17:30 | Leeds United | 0 : 3 | Liverpool |
| 12.09.2021 15:00 | Cagliari | 2 : 3 | Genoa | |
| 12.09.2021 18:00 | Milan | 2 : 0 | Lazio | |
| 12.09.2021 20:45 | Roma | 2 : 1 | Sassuolo | |
| 12.09.2021 12:30 | Sampdoria | 2 : 2 | Inter | |
| 12.09.2021 15:00 | Spezia | 0 : 1 | Udinese | |
| 12.09.2021 15:00 | Torino | 4 : 0 | Salernitana |
| 12.09.2021 15:30 | Eintracht | 1 : 1 | Stuttgart | |
| 12.09.2021 17:30 | Bochum | 1 : 3 | Hertha BSC | |
| 12.09.2021 19:30 | Borussia M'gladbach | 3 : 1 | Arminia |
| 12.09.2021 15:30 | Nottingham Forest | 1 : 2 | Cardiff City |
| 12.09.2021 18:30 | Cadiz | 0 : 2 | Real Sociedad | |
| 12.09.2021 14:00 | Espanyol | 1 : 2 | Atletico Madrid | |
| 12.09.2021 16:15 | Osasuna | 1 : 4 | Valencia | |
| 12.09.2021 21:00 | Real Madrid | 5 : 2 | Celta Vigo |
| 12.09.2021 11:00 | ŽGFK Lavice Dubočica | 0 : 0 | Radnički 1923 | |
| 12.09.2021 11:00 | Karađorđe | 0 : 3 | Kolubara |
| 12.09.2021 12:00 | Una Fortuna | 0 : 3 | Slatke male |
| 12.09.2021 16:30 | Stajićevo 2017 | 3 : 0 | Voša AS | |
| 12.09.2021 13:00 | Nova Kolonija | 1 : 3 | Moskva | |
| 12.09.2021 17:00 | Banat | 0 : 3 | Proleter |
| 12.09.2021 00:00 | Rad | 1 : 1 | Heroj Polet | |
| 12.09.2021 00:00 | Desetka | : | Vinča |
| 12.09.2021 13:00 | Zemun | 1 : 3 | Čukarički | |
| 12.09.2021 11:30 | OFK Beograd | : | Mladost (L) | |
| 12.09.2021 11:00 | Radnički 1923 | 4 : 0 | Spartak ŽK |
| 12.09.2021 13:30 | Šumadija 1903 | 2 : 0 | Radnički (V) | |
| 12.09.2021 13:30 | Jedinstvo | 1 : 2 | Zlatibor | |
| 12.09.2021 13:30 | Loznica | 4 : 0 | Železničar | |
| 12.09.2021 13:30 | Metalac (GM) | 4 : 1 | Sunrise Šabac | |
| 12.09.2021 13:30 | Sloga (P) | : | Mladost (L) | |
| 12.09.2021 13:30 | Javor | 3 : 0 | Mladi radnik 1926 | |
| 12.09.2021 13:30 | Sloga (K) | 2 : 1 | GFK Sloboda | |
| 12.09.2021 13:30 | Borac 1926 | 0 : 2 | Novi Pazar |
| 12.09.2021 | GFK Jagodina | 0 : 1 | Trayal |
| 12.09.2021 | OFK Topličanin | 4 : 1 | GFK Dubočica |
| 12.09.2021 10:00 | Prof. Bolesnikov | 1 : 1 | Spartak ŽK | |
| 12.09.2021 10:00 | Vojvodina | 4 : 0 | Kabel |
| 12.09.2021 10:00 | Omladinac | 3 : 0 | Radnički (Š) | |
| 12.09.2021 10:00 | Radnički (Zr) | 2 : 7 | OFK Vršac | |
| 12.09.2021 10:00 | Inđija | 6 : 2 | GFK Sloven | |
| 12.09.2021 10:00 | Petar Puača | 5 : 3 | Dinamo 1945 | |
| 12.09.2021 10:00 | Radnički (NP) | 0 : 4 | Radnički (SM) |
| 12.09.2021 10:00 | Internacional | 1 : 2 | Zvezdara | |
| 12.09.2021 16:00 | Sinđelić | 2 : 1 | Radnički | |
| 12.09.2021 10:00 | BSK Borča | 5 : 4 | Brodarac 2 |
| 12.09.2021 12:00 | Radnički (K) | 3 : 0 | Hajduk | |
| 12.09.2021 10:00 | Veternik | 8 : 0 | 1. Maj |
| 12.09.2021 10:00 | Budućnost Krušik 2014 | 2 : 0 | Radnički (K) | |
| 12.09.2021 10:00 | Jedinstvo Putevi | : | Zlatibor | |
| 12.09.2021 10:00 | Takovo | : | Budućnost (A) | |
| 12.09.2021 10:00 | Crnokosa | 0 : 4 | Karađorđe | |
| 12.09.2021 10:00 | Novi Pazar | : | OFK Senjak |
| 12.09.2021 20:00 | 011 | 0 : 2 | Lokomotiva | |
| 12.09.2021 10:00 | IMT | 1 : 0 | Sinđelić |
| 12.09.2021 11:00 | Šumadija 1903 | 1 : 0 | Radnički (V) | |
| 12.09.2021 11:00 | Jedinstvo | 2 : 1 | Mačva | |
| 12.09.2021 11:00 | Loznica | 1 : 4 | Apolon 4 | |
| 12.09.2021 11:00 | Metalac (GM) | 1 : 1 | Sunrise Šabac | |
| 12.09.2021 11:00 | Savacijum | 4 : 1 | Radnički 1923 | |
| 12.09.2021 11:00 | Javor | 0 : 1 | Apolon 2018 | |
| 12.09.2021 11:00 | Sloga (K) | 4 : 2 | GFK Sloboda | |
| 12.09.2021 11:00 | Borac 1926 | 0 : 1 | Novi Pazar |
| 12.09.2021 | GFK Jagodina | 5 : 0 | Timočanin | |
| 12.09.2021 | SFS Borac | 0 : 10 | Radnički 2 | |
| 12.09.2021 | GFK Dubočica | 2 : 2 | Radnički (P) | |
| 12.09.2021 | Vlasina | 2 : 1 | Budućnost |
| 12.09.2021 12:00 | Prof. Bolesnikov | 1 : 4 | Spartak ŽK | |
| 12.09.2021 11:00 | Proleter (NS) | 3 : 1 | OFK Bačka |
| 12.09.2021 12:00 | Omladinac | 2 : 0 | Podrinje | |
| 12.09.2021 12:00 | Radnički (Zr) | 2 : 2 | OFK Vršac | |
| 12.09.2021 12:00 | Inđija | 1 : 4 | ODR | |
| 12.09.2021 12:00 | Petar Puača | 5 : 1 | Dinamo 1945 |
| 12.09.2021 10:00 | Radničkin(NB) | 0 : 1 | Kolubara |
| 12.09.2021 12:00 | Spartak 1976 | 5 : 0 | Takovo | |
| 12.09.2021 12:00 | Čačak 94 | : | Sloga (BB) | |
| 12.09.2021 12:00 | Jedinstvo Putevi | 2 : 1 | Zlatibor | |
| 12.09.2021 12:00 | Polimlje | : | FAP |
| 12.09.2021 10:00 | Kiker | : | Bubamara | |
| 12.09.2021 10:00 | Novi Pazar | 7 : 0 | Karađorđe | |
| 12.09.2021 10:00 | Jedinstvo 2017 | 3 : 1 | Trepča | |
| 12.09.2021 10:00 | Tutin | : | Bane 1931 |
| 12.09.2021 10:00 | Arena Su | 2 : 1 | OFK Kikinda | |
| 12.09.2021 10:00 | Petrika | 2 : 1 | Derby 2015 |
| 12.09.2021 10:00 | OPK Rudar 1933 | 5 : 0 | VGSK | |
| 12.09.2021 10:00 | Đerdap | : | Železničar | |
| 12.09.2021 10:00 | Smederevo 1924 | 13 : 0 | Jasenica 2017 | |
| 12.09.2021 10:00 | Rudar (S) | : | Šumadija (A) | |
| 12.09.2021 10:00 | Radnički 1923 | 2 : 2 | Arsenal | |
| 12.09.2021 10:00 | Sušica | 0 : 1 | Mladi radnik 1926 |
| 12.09.2021 10:00 | Tavankut | 7 : 3 | Sloga | |
| 12.09.2021 10:00 | Radnički 1905 | 1 : 4 | Bačka 1901 |
| 12.09.2021 13:00 | TEK Sloga | 3 : 5 | Borac (L) |
| 12.09.2021 16:00 | RFK Grafičar | 0 : 0 | OFK Beograd | |
| 12.09.2021 13:00 | Radnički (NB) | 0 : 7 | Čukarički | |
| 12.09.2021 09:00 | Teleoptik | 5 : 2 | Lokomotiva | |
| 12.09.2021 18:00 | 011 | 2 : 0 | Sinđelić | |
| 12.09.2021 12:30 | Brodarac | 4 : 0 | OLE | |
| 12.09.2021 11:00 | Rad |