| 25.04.2021 14:30 | Vojvodina | 1 : 2 | Metalac | |
| 25.04.2021 17:00 | Inđija | 1 : 5 | Crvena zvezda | |
| 25.04.2021 14:30 | Radnik | 0 : 0 | Radnički (N) | |
| 25.04.2021 19:30 | Partizan | 2 : 1 | Spartak ŽK |
| 25.04.2021 16:30 | Trayal | 2 : 3 | IMT | |
| 25.04.2021 18:00 | Kolubara | 2 : 1 | Radnički (P) |
| 25.04.2021 19:00 | Borac | 2 : 1 | Široki Brijeg | |
| 25.04.2021 17:00 | Željezničar | 1 : 2 | Olimpik | |
| 25.04.2021 15:00 | Tuzla City | 2 : 0 | Radnik |
| 25.04.2021 16:30 | Dunav | 1 : 1 | Dinamo 1945 | |
| 25.04.2021 16:30 | Vojvodina 1928 | 0 : 0 | Jedinstvo (SP) |
| 25.04.2021 16:00 | Bane 1931 | 0 : 3 | Železničar (L) | |
| 25.04.2021 16:00 | Sušica | 0 : 0 | Trepča |
| 25.04.2021 13:00 | Brodarac | 2 : 0 | Mladenovac | |
| 25.04.2021 16:30 | Zvezdara | 5 : 2 | Leštane |
| 25.04.2021 16:30 | Vlasina | 1 : 3 | SFS Borac | |
| 25.04.2021 16:30 | Budućnost (P) | 1 : 0 | Radnički (S) | |
| 25.04.2021 11:00 | Car Konstantin | 0 : 1 | Timok 1919 | |
| 25.04.2021 16:30 | Župa | 0 : 4 | Trstenik PPT | |
| 25.04.2021 16:30 | Rembas | 7 : 2 | Kablovi | |
| 25.04.2021 16:30 | Radan | 0 : 1 | Jedinstvo (P) | |
| 25.04.2021 16:30 | Timočanin | 5 : 1 | Mladost |
| 25.04.2021 16:00 | Real | 3 : 0 | Polet | |
| 25.04.2021 11:00 | Proleter | 1 : 0 | Goč | |
| 25.04.2021 16:00 | Radnik | 0 : 0 | Budućnost | |
| 25.04.2021 16:00 | Vodojaža | 2 : 0 | Korićani | |
| 25.04.2021 16:00 | OFK Ras | 3 : 1 | Novi Pazar 1928 |
| 25.04.2021 16:00 | OFK Napredak | 6 : 0 | Jasenica 2017 | |
| 25.04.2021 16:00 | Pomoravlje | 2 : 1 | RSK | |
| 25.04.2021 16:00 | Sloboda | 3 : 0 | OFK Aranđelovac 1979 | |
| 25.04.2021 16:00 | Sloga (B) | 2 : 1 | Rudar (S) | |
| 25.04.2021 16:00 | Borac 1932 | 3 : 1 | Petar Dobrnjac | |
| 25.04.2021 16:00 | OFK Mihajlovac | 3 : 0 | Morava (VP) | |
| 25.04.2021 16:00 | Đerdap | 6 : 1 | VGSK | |
| 25.04.2021 16:00 | Karađorđe | 3 : 0 | Sloga (M) | |
| 25.04.2021 16:00 | Zvižd | 3 : 2 | Borac (Ž) |
| 25.04.2021 16:00 | Sloboda (Č) | 1 : 1 | Jedinstvo Putevi | |
| 25.04.2021 16:00 | Jasen | 2 : 1 | Sevojno | |
| 25.04.2021 16:00 | Rampa | 0 : 0 | Parmenac | |
| 25.04.2021 16:00 | Polet (T) | 5 : 1 | Omladinac | |
| 25.04.2021 16:00 | Prijevor | 1 : 1 | Polet (Lj) |
| 25.04.2021 16:00 | Sloga (B) | 4 : 1 | Rubribreza | |
| 25.04.2021 16:00 | Mladost (Dr) | 5 : 0 | Spartak 1924 | |
| 25.04.2021 16:00 | Borac (L) | 3 : 3 | Mladost (P) | |
| 25.04.2021 16:00 | Zadrugar | 1 : 0 | Ribnica | |
| 25.04.2021 16:00 | Radnički (K) | 3 : 4 | Mladost (DD) | |
| 25.04.2021 16:00 | OFK Divci | 3 : 1 | Radnički (V) |
| 25.04.2021 16:30 | Hercegovac | 3 : 4 | Vojvodina (T) | |
| 25.04.2021 16:00 | Bačka (P) | 2 : 0 | OFK Vrbas | |
| 25.04.2021 16:30 | Mladost (T) | 3 : 2 | Vojvodina (BG) | |
| 25.04.2021 16:30 | Mladost (BP) | 3 : 0 | Radnički (S) |
| 25.04.2021 16:30 | Radnički (K) | 3 : 1 | Mladost | |
| 25.04.2021 16:30 | ŽAK | 2 : 3 | Borac | |
| 25.04.2021 16:30 | Crvena zvezda | 0 : 0 | Banat |
| 25.04.2021 10:00 | Index | 0 : 1 | Podunavac | |
| 25.04.2021 16:30 | Jedinstvo | 3 : 0 | Sloga (E) | |
| 25.04.2021 16:30 | Borac | 5 : 1 | Podrinje | |
| 25.04.2021 16:30 | Hajduk | 3 : 1 | Cement | |
| 25.04.2021 16:30 | Budućnost | 3 : 1 | Jugović | |
| 25.04.2021 16:30 | Jadran | 0 : 3 | Sloboda |
| 25.04.2021 16:30 | Levač | 2 : 0 | Jedinstvo 1936 | |
| 25.04.2021 16:30 | Sloga (M) | 1 : 1 | OFK Lugomir | |
| 25.04.2021 16:30 | Juhor | 1 : 3 | Meševo | |
| 25.04.2021 16:30 | Kušiljevo | 1 : 2 | Morava 1918 | |
| 25.04.2021 16:30 | Jastrebac | 2 : 1 | Bošnjane | |
| 25.04.2021 16:30 | Jedinstvo (M) | 3 : 1 | Temnić 1924 |
| 25.04.2021 16:30 | Lužnica | 0 : 1 | Bor 1919 | |
| 25.04.2021 16:30 | Branik | 1 : 2 | Tanasko Rajić | |
| 25.04.2021 16:30 | OFK 019 | 3 : 3 | Rajko Mitić | |
| 25.04.2021 11:00 | Jedinstvo (P) | 1 : 3 | Senjak | |
| 25.04.2021 16:30 | OFK Slatina | 0 : 1 | Hajduk Veljko |
| 25.04.2021 16:30 | Naša krila 1936 | 3 : 1 | OFK Napredak 1929 | |
| 25.04.2021 16:30 | OFK Niš | 2 : 0 | Zemljoradnik | |
| 25.04.2021 16:30 | Morava | 4 : 0 | Orljane | |
| 25.04.2021 16:30 | OFK Brzi Brod | 0 : 0 | Jedinstvo (GM) | |
| 25.04.2021 16:30 | Malošište | 3 : 0 | Bukovik | |
| 25.04.2021 13:00 | Naisus 1977 | 1 : 10 | Delijski Vis |
| 25.04.2021 16:30 | Svetlost | 3 : 1 | Jedinstvo (GS) | |
| 25.04.2021 16:30 | Jablanica | 3 : 2 | Vranjska Banja | |
| 25.04.2021 16:30 | Čekmin | 1 : 1 | OFK Kosanica | |
| 25.04.2021 16:30 | Jedinstvo (G) | 3 : 4 | Alakince | |
| 25.04.2021 16:30 | Žitorađa | 6 : 3 | Budućnost |
| 25.04.2021 10:00 | Torlak | 0 : 0 | Komgrap | |
| 25.04.2021 16:30 | Kosmaj | 2 : 2 | BSK 1926 | |
| 25.04.2021 16:30 | Poštar Zvezdara | 4 : 0 | Mladost (C) | |
| 25.04.2021 16:30 | Srem | 0 : 3 | Prva iskra | |
| 25.04.2021 10:00 | Borac (L) | 6 : 0 | Dunav |
| 25.04.2021 16:30 | Velika Jasikova | 3 : 0 | Osnić | |
| 25.04.2021 16:30 | Trebič | 6 : 1 | Kosovo | |
| 25.04.2021 16:30 | Graničar | 7 : 1 | Hajduk | |
| 25.04.2021 16:30 | Omladinac | 1 : 0 | Radnički 1946 | |
| 25.04.2021 16:30 | OFK Rtanj | 2 : 0 | Rudar (P) |
| 25.04.2021 16:30 | Mačkovac | 2 : 1 | FUD | |
| 25.04.2021 16:30 | Gradina | 4 : 2 | Ribnik | |
| 25.04.2021 16:30 | Kupci | 1 : 3 | Sebečevac | |
| 25.04.2021 16:30 | Donji Kopaonik | 2 : 2 | Žabare | |
| 25.04.2021 16:30 | Sloga (L) | 0 : 1 | 13. April | |
| 25.04.2021 16:30 | Sloga (D) | 3 : 1 | Mladost (DK) |
| 25.04.2021 16:30 | Sremac | 0 : 2 | Radnički | |
| 25.04.2021 16:30 | Sloga | 2 : 1 | Partizan | |
| 25.04.2021 16:30 | Napredak | 9 : 0 | LSK | |
| 25.04.2021 16:30 | BSK | 4 : 0 | Borac (K) | |
| 25.04.2021 16:30 | Donji Srem 2015 | 2 : 0 | Hajduk (B) | |
| 25.04.2021 16:30 | Mitros | 5 : 1 | PSK |
| 25.04.2021 16:30 | Partizan (G) | 4 : 2 | Jugoslavija | |
| 25.04.2021 16:30 | Polet (Id) | 4 : 0 | Spartak 1911 | |
| 25.04.2021 16:30 | Potporanj | 3 : 1 | Banat (I) | |
| 25.04.2021 16:30 | Sloga (BNS) | 2 : 0 | Partizan (U) | |
| 25.04.2021 16:30 | Stari Tamiš | 2 : 1 | Hajdučica | |
| 25.04.2021 16:30 | Budućnost (A) | 5 : 0 | Radnički (B) | |
| 25.04.2021 16:30 | Dolina | 1 : 5 | Strela |
| 25.04.2021 16:30 | Budućnost (M) | 0 : 1 | ŽAK | |
| 25.04.2021 16:30 | BSK | 4 : 0 | Slavija | |
| 25.04.2021 16:30 | Radnički 1918 | 1 : 1 | Kulpin | |
| 25.04.2021 16:30 | SU Stanišić 1920 | 4 : 1 | Maglić | |
| 25.04.2021 16:30 | Zadrugar | 1 : 1 | Borac (BG) | |
| 25.04.2021 16:30 | Budućnost (P) | 3 : 2 | Omladinac | |
| 25.04.2021 16:30 | Kordun | 1 : 0 | Rusin | |
| 25.04.2021 16:30 | Borac 46 | 3 : 1 | Budućnost (G) |
| 25.04.2021 17:00 | Preporod | 3 : 1 | Iskra | |
| 25.04.2021 17:00 | Obilić | 0 : 1 | AFK | |
| 25.04.2021 17:00 | Budućnost | 1 : 2 | Sutjeska | |
| 25.04.2021 17:00 | Jadran | 2 : 0 | Đurđin |
| 25.04.2021 16:30 | Polet | 3 : 0 | MSK | |
| 25.04.2021 16:30 | Borac | 3 : 0 | Radnički 1911 | |
| 25.04.2021 16:30 | Vojvodina (NM) | 2 : 1 | ASK | |
| 25.04.2021 16:30 | 2. Oktobar | 3 : 4 | Vojvodina (B) | |
| 25.04.2021 16:30 | Mladost (BD) | 1 : 0 | Potisje | |
| 25.04.2021 16:30 | OFK Klek | 0 : 4 | Crvena zvezda | |
| 25.04.2021 16:30 | Rusanda | 4 : 1 | Lehel |
| 25.04.2021 16:00 | Polet | 2 : 1 | Obilić | |
| 25.04.2021 16:00 | Radnik (SP) | 3 : 2 | Budućnost | |
| 25.04.2021 16:00 | SASK | 1 : 3 | Pobeda | |
| 25.04.2021 16:00 | Bresje Superior | 1 : 0 | Sloga (M) | |
| 25.04.2021 16:00 | Osipaonica | 1 : 0 | Podunavac | |
| 25.04.2021 16:00 | Bačinac | 4 : 1 | Mladost 1948 | |
| 25.04.2021 16:00 | Mladi borac | 3 : 0 | Crvena zvezda | |
| 25.04.2021 16:00 | Mladi radnik 1940 | 1 : 1 | Sloga (L) |
| 25.04.2021 16:00 | Prvi srpski ustanak | 2 : 1 | Šumadinac 1913 | |
| 25.04.2021 16:00 | Partizan 1945 | 0 : 7 | BSK | |
| 25.04.2021 16:00 | Grizli ML | 4 : 0 | Borac (P) | |
| 25.04.2021 16:00 | Vinča | 0 : 3 | Banja 1957 | |
| 25.04.2021 16:00 | Partizan (BB) | 3 : 0 | Jasenica (B) | |
| 25.04.2021 16:00 | Šumadinac (S) | 3 : 3 | Trnava | |
| 25.04.2021 16:00 | Sloga (Z) | 2 : 1 | Omladinac | |
| 25.04.2021 16:00 | Lokomotiva | 0 : 1 | ŽSK | |
| 25.04.2021 16:00 | Marjan (K) | 2 : 0 | Plaskovac |
| 25.04.2021 16:30 | PKB Kovilovo | 4 : 1 | Sinđelić 2012 | |
| 25.04.2021 16:30 | Umka | 2 : 1 | 011 | |
| 25.04.2021 16:30 | Heroj Polet | 4 : 2 | Šumadinac | |
| 25.04.2021 16:30 | Posavac Tišma | 4 : 0 | Borac (P) | |
| 25.04.2021 16:30 | Balkan Mirijevo | 1 : 0 | Postar 1930 | |
| 25.04.2021 16:30 | DIF | 0 : 0 | Institut |
| 25.04.2021 16:30 | Jedinstvo | 2 : 2 | Mladi borac | |
| 25.04.2021 16:30 | Zvezda | 3 : 0 | Omladinac | |
| 25.04.2021 16:30 | OFK Borac | 1 : 1 | Strelac | |
| 25.04.2021 16:30 | OFK Zabrežje | 2 : 0 | Vranić | |
| 25.04.2021 16:30 | OFK Budućnost | 1 : 2 | Radnički | |
| 25.04.2021 16:30 | Duboko | 1 : 1 | Lisović 1977 |
| 25.04.2021 16:30 | SUF Dubona | 0 : 0 | Pudarci | |
| 25.04.2021 16:30 | Zaklopača | 0 : 3 | Velika Krsna | |
| 25.04.2021 16:30 | Kosmajac | 1 : 6 | Kaluđerica 1969 | |
| 25.04.2021 16:30 | Boleč | 1 : 0 | Rabrovac | |
| 25.04.2021 16:30 | SUF Kovačevac 1956 | 2 : 1 | Ivanča | |
| 25.04.2021 16:30 | Šumadija 1962 | 1 : 7 | Zuce 2019 |
| 25.04.2021 17:00 | Tatra | 3 : 0 | Titel | |
| 25.04.2021 17:00 | Bačka 1923 | 1 : 4 | Jedinstvo | |
| 25.04.2021 17:00 | Petrovaradin | 2 : 1 | Susek | |
| 25.04.2021 17:00 | ŽSK | 1 : 2 | Šajkaš 1908 | |
| 25.04.2021 17:00 | Fruškogorac | 1 : 5 | Veternik | |
| 25.04.2021 17:00 | OFK Sirig | 0 : 2 | Slavija |
| 25.04.2021 16:30 | Nemetali | 3 : 1 | Urovica | |
| 25.04.2021 11:00 | Sloga | 1 : 2 | Šarbanovac | |
| 25.04.2021 16:30 | Polet | 2 : 0 | BSK | |
| 25.04.2021 16:30 | Blizna | 3 : 1 | Mladost |
| 25.04.2021 16:30 | Šumadinac KG | 2 : 1 | Maršić | |
| 25.04.2021 16:30 | Zastava | 1 : 0 | Pobeda 1926 | |
| 25.04.2021 16:30 | Jedinstvo | 1 : 5 | Sloboda (G) | |
| 25.04.2021 16:30 | Kutlovo | 4 : 0 | Mladost (P) | |
| 25.04.2021 16:30 | Šumadija 1934 | 4 : 0 | OFK Bagremar |
| 25.04.2021 16:30 | Omladinac | 3 : 3 | Mladost (L) | |
| 25.04.2021 16:30 | Sloboda | 3 : 0 | Morava | |
| 25.04.2021 16:30 | Mladost (DK) | 0 : 1 | Čegar 1946 | |
| 25.04.2021 16:30 | Stevan Nešticki | 3 : 1 | Crvena zastava | |
| 25.04.2021 16:30 | Radnički 1936 | 1 : 2 | Čegar 2013 | |
| 25.04.2021 16:30 | Vulkan 1963 | 1 : 1 | Aluminjum | |
| 25.04.2021 16:30 | Planinac 1933 | 2 : 3 | Palilulac |
| 25.04.2021 16:00 | Vihor | 1 : 1 | Napredak 1936 | |
| 25.04.2021 16:00 | Mladost (B) | 5 : 0 | Manastirica | |
| 25.04.2021 16:00 | Rudar (Kr) | 4 : 2 | Železničar | |
| 25.04.2021 16:00 | Borac (K) | 1 : 0 | Omladinac (Š) | |
| 25.04.2021 16:00 | Mlava (ML) | 0 : 4 | Napredak Simićevo | |
| 25.04.2021 16:00 | Sirakovo | 1 : 1 | Rudar 2001 | |
| 25.04.2021 16:00 | Sloga (L) | 3 : 2 | Obilić |
| 25.04.2021 16:30 | Rasovača | 1 : 2 | Moravac (ZT) | |
| 25.04.2021 16:30 | Sloga | 1 : 1 | Svrljig | |
| 25.04.2021 16:30 | Radnički 1924 | 3 : 0 | OFK Rutevac 1908 | |
| 25.04.2021 11:00 | Palilula | 2 : 5 | Taskovići | |
| 25.04.2021 16:30 | Borac | 2 : 2 | Baličevac | |
| 25.04.2021 16:30 | Radnički 1947 | 3 : 0 | Moravac (Č) |
| 25.04.2021 16:30 | Gruža | 1 : 2 | Ribnica | |
| 25.04.2021 16:30 | Budućnost | 1 : 0 | Napredak | |
| 25.04.2021 16:30 | Jovo Kursula | 1 : 5 | Tavnik | |
| 25.04.2021 16:30 | Granit | 4 : 0 | Popovići Vrnjci |
| 25.04.2021 16:30 | Partizan | 2 : 0 | Juhor (G) | |
| 25.04.2021 16:30 | Orlovi | 5 : 0 | Kolare | |
| 25.04.2021 16:30 | Napredak | 6 : 0 | Resavac | |
| 25.04.2021 16:30 | OFK Juhor 2016 | 4 : 3 | Mladost (K) | |
| 25.04.2021 16:30 | Dragocvet | 1 : 0 | Budućnost (Đ) | |
| 25.04.2021 16:30 | Mladost (J) | 3 : 1 | Javor | |
| 25.04.2021 16:30 | Sloga | 3 : 1 | Rudar |
| 25.04.2021 16:00 | Banjani | 1 : 0 | Joks Junajted | |
| 25.04.2021 16:00 | Trlić | 3 : 1 | Kolubara 2 | |
| 25.04.2021 16:00 | Pambukovica | 0 : 3 | OFK Senjak | |
| 25.04.2021 16:00 | Tvrdojevac | 0 : 3 | Dimitrije Tucović |
| 25.04.2021 11:00 | Bratstvo | 1 : 2 | Kumarevo 65 | |
| 25.04.2021 16:30 | Bobište | 7 : 1 | Zloćudovo | |
| 25.04.2021 16:30 | Umac | 0 : 0 | Gradac | |
| 25.04.2021 16:30 | OFK Brza | 2 : 3 | Progres | |
| 25.04.2021 16:30 | Polet | 1 : 0 | Donja Lomnica |
| 25.04.2021 16:30 | OFK Morava | 4 : 2 | BSK | |
| 25.04.2021 16:30 | Real | 5 : 4 | Šumadija | |
| 25.04.2021 16:30 | Plantaža | 3 : 0 | Milanovo | |
| 25.04.2021 16:30 | Moravac | 2 : 1 | Sloboda | |
| 25.04.2021 16:30 | Sloga | 2 : 0 | Železničar | |
| 25.04.2021 16:30 | Mladost 1959 | 1 : 1 | Mladi borac |
| 25.04.2021 11:00 | Prvi partizan | 6 : 3 | Kotroman | |
| 25.04.2021 16:00 | Savinac | 3 : 2 | Jedinstvo | |
| 25.04.2021 16:00 | Višesava | 2 : 4 | Polet | |
| 25.04.2021 16:00 | Bakionica | 1 : 0 | Čajetina | |
| 25.04.2021 16:00 | Ježevica | 3 : 1 | Avijatičar Vranjani | |
| 25.04.2021 16:00 | Omladinac | 0 : 3 | Sečica | |
| 25.04.2021 16:00 | Lazarica | 8 : 1 | Perućac |
| 25.04.2021 16:00 | Ozremica | 0 : 0 | Prilike | |
| 25.04.2021 16:00 | Spartak | 2 : 1 | Voćar | |
| 25.04.2021 16:00 | Morava | 1 : 3 | Ovčar | |
| 25.04.2021 16:00 | Dragačevo | 1 : 0 | Rakova | |
| 25.04.2021 16:00 | Jedinstvo | 1 : 4 | Slatina |
| 25.04.2021 16:00 | Rudar | 1 : 2 | Mladost (P) | |
| 25.04.2021 16:00 | Orlovac | 1 : 1 | Jedinstvo (GG) | |
| 25.04.2021 16:00 | Backovac Junajted | 2 : 1 | Napredak | |
| 25.04.2021 16:00 | Jedinstvo (K) | 4 : 0 | Zadrugar | |
| 25.04.2021 16:00 | Donja Vrbava | 0 : 5 | Ozrem PMH |
| 25.04.2021 16:00 | Napredak | 3 : 2 | Dragoš | |
| 25.04.2021 16:00 | Pobeda | 2 : 3 | Vladimir Durković | |
| 25.04.2021 16:00 | Spartak | 1 : 0 | Gnjilan |
| 25.04.2021 16:30 | Hajduk Stanko | 3 : 3 | Podrinje | |
| 25.04.2021 16:30 | Rudar | 2 : 0 | Sloga (KR) | |
| 25.04.2021 16:30 | Mladost | 0 : 4 | Vidojevica | |
| 25.04.2021 16:30 | Milan Orlić | 2 : 1 | Cer (JL) | |
| 25.04.2021 16:30 | Drina | 5 : 0 | Mladi borac | |
| 25.04.2021 16:30 | Duško | 3 : 2 | Sloga (LŠ) | |
| 25.04.2021 16:30 | Majur | 3 : 0 | Sinđelić |
| 25.04.2021 16:00 | Mladost (B) | 2 : 5 | Lugina | |
| 25.04.2021 16:00 | BSK Bujanovac | 1 : 2 | Levosoje | |
| 25.04.2021 16:00 | Čelik | 0 : 3 | Trnovac | |
| 25.04.2021 16:00 | Mineralac | 2 : 2 | Pavlovac | |
| 25.04.2021 16:00 | FSU Južna pruga | 3 : 0 | Vihor |
| 25.04.2021 16:30 | Omladinac (U) | 0 : 0 | Garevina | |
| 25.04.2021 16:30 | 14. Oktobar | 0 : 1 | Velika Drenova | |
| 25.04.2021 16:30 | Borac | 5 : 0 | Gradac | |
| 25.04.2021 16:30 | Rubin | 4 : 3 | Stari Trstenik |
| 25.04.2021 16:30 | Borac (VS) | 2 : 2 | Polet | |
| 25.04.2021 16:30 | Ratar | 2 : 0 | Graničar | |
| 25.04.2021 16:30 | Dunav | 3 : 0 | Ševac | |
| 25.04.2021 16:30 | Omladinac | 3 : 3 | Karaš (K) | |
| 25.04.2021 16:30 | Borac (VG) | 2 : 1 | Partizan (K) | |
| 25.04.2021 16:30 | Karaš (J) | 1 : 0 | Vulturul |
| 25.04.2021 16:30 | BSK Bavanište | 2 : 0 | Borac (P) | |
| 25.04.2021 16:30 | Budućnost (BB) | 1 : 5 | Dolovo | |
| 25.04.2021 16:30 | Jedinstvo (D) | 2 : 3 | Mladost (V) | |
| 25.04.2021 16:30 | Omladinac (D) | 0 : 0 | Proleter |
| 25.04.2021 16:30 | OFK Brestač | 1 : 2 | ČSK | |
| 25.04.2021 16:30 | Kameni | 0 : 2 | Napredak | |
| 25.04.2021 16:30 | Sremac | 0 : 3 | Fruškogorac | |
| 25.04.2021 16:30 | Mladost | 3 : 4 | Polet | |
| 25.04.2021 16:30 | Dunav | 0 : 2 | Krušedol | |
| 25.04.2021 16:30 | Radnički | 0 : 0 | Jedinstvo | |
| 25.04.2021 16:30 | Hrtkovci | 2 : 1 | Srem | |
| 25.04.2021 16:30 | Šumar | 2 : 0 | Graničar |
| 25.04.2021 16:30 | Zmaj | 3 : 1 | Graničar 1924 | |
| 25.04.2021 16:30 | Fruškogorac | 3 : 0 | OFK Zeka Buljubaša | |
| 25.04.2021 16:30 | Sremac (B) | 2 : 2 | Jedinstvo | |
| 25.04.2021 16:30 | Sremac (J) | 3 : 0 | Jednota | |
| 25.04.2021 16:30 | Graničar (K) | 2 : 0 | Erdevik 2017 | |
| 25.04.2021 10:00 | Fruška Gora | 2 : 1 | OFK Bikić | |
| 25.04.2021 16:30 | Trgovački | 0 : 2 | Obilić 1993 | |
| 25.04.2021 16:30 | Sloboda | 6 : 1 | Sloga |
| 25.04.2021 16:30 | Zlatica | 1 : 6 | Naftagas | |
| 25.04.2021 16:30 | OFK Stajićevo | 7 : 1 | Tisa 1933 | |
| 25.04.2021 16:30 | Mladost | 1 : 2 | Zadrugar | |
| 25.04.2021 16:30 | Bilećanin | 4 : 2 | OFK Gradnulica |
| 25.04.2021 11:00 | Borac | 1 : 1 | B 2000 | |
| 25.04.2021 16:00 | Šamot | 0 : 0 | Vrbica | |
| 25.04.2021 11:00 | Trešnjevica | 3 : 3 | Gorski Car | |
| 25.04.2021 11:00 | Kopljari | 2 : 0 | Budućnost | |
| 25.04.2021 16:00 | Mladi rudar | 3 : 0 | Mladost (J) | |
| 25.04.2021 16:00 | Venčani | 4 : 2 | Radoje Domanović |
| 25.04.2021 16:00 | Napredak (MK) | 2 : 2 | Mladi radnik (D) | |
| 25.04.2021 16:00 | Kruševica 1980 | 4 : 1 | Šumadija (S) | |
| 25.04.2021 16:00 | Sloga (Z) | 1 : 1 | Badnjevac | |
| 25.04.2021 16:00 | Mladost (R) | 1 : 0 | Karađorđe (V) | |
| 25.04.2021 11:00 | Čestin | 0 : 1 | BSK |
| 25.04.2021 16:30 | Terekveš | 2 : 0 | Hajduk | |
| 25.04.2021 16:30 | Lipar | 3 : 0 | Dunav | |
| 25.04.2021 16:30 | Bratstvo 2019 | 12 : 0 | Dinamo 1923 | |
| 25.04.2021 16:30 | Polet | 1 : 1 | Jedinstvo | |
| 25.04.2021 16:30 | OFK Odžaci | 2 : 0 | Mladost | |
| 25.04.2021 16:30 | Aleksa Šantić | 1 : 1 | Kula |
| 25.04.2021 10:00 | OFK Hajduk | 1 : 3 | Dinamo | |
| 25.04.2021 17:00 | Borac (R) | 8 : 0 | Železničar | |
| 25.04.2021 17:00 | Proleter | 2 : 1 | Hajduk (G) | |
| 25.04.2021 17:00 | Sloga | 1 : 1 | Moskva |
| 25.04.2021 16:30 | Ćava | 1 : 2 | Dobrača | |
| 25.04.2021 16:30 | Partizan | 0 : 3 | Divostin | |
| 25.04.2021 16:30 | Košutnjak | 4 : 1 | Seljak |
| 25.04.2021 16:00 | Barič | 0 : 4 | Žitkovica | |
| 25.04.2021 16:00 | BSK 1931 | 3 : 2 | Napredak (P) | |
| 25.04.2021 16:00 | Stig 1955 | 2 : 1 | Batovac | |
| 25.04.2021 16:00 | Mladi Borac | 2 : 1 | Dizel | |
| 25.04.2021 16:00 | Napredak (B) | 4 : 1 | Pek | |
| 25.04.2021 16:00 | Mlava (B) | 2 : 0 | Baštovan 2015 | |
| 25.04.2021 16:00 | Sloga (M) | 5 : 4 | Ljubičevo | |
| 25.04.2021 16:00 | Polet (V) | 2 : 1 | Borac 2016 |
| 25.04.2021 16:30 | Velika Moštanica | 4 : 3 | BUSK | |
| 25.04.2021 16:30 | Novi Beograd | 3 : 0 | Rekreativo 011 | |
| 25.04.2021 12:00 | Dedinje | 2 : 1 | Zmaj 1953 |
| 25.04.2021 13:00 | Lepušnica | 4 : 1 | Pionir | |
| 25.04.2021 16:30 | Palilulac | 1 : 0 | Avala 1939 | |
| 25.04.2021 16:30 | Minel | 7 : 2 | Boka Seniors | |
| 25.04.2021 16:30 | OFK Crvenka | 2 : 5 | Siti Sport Klub | |
| 25.04.2021 16:30 | Resnik | 4 : 1 | Mladi proleter | |
| 25.04.2021 16:30 | Pinosava | 4 : 0 | Sveti Stefan |
| 25.04.2021 16:30 | OFK Boždarevac | 3 : 0 | Veliki Borak | |
| 25.04.2021 16:30 | Beljina | 7 : 2 | Rušanj |
| 25.04.2021 16:30 | Borac (A) | 1 : 5 | Borac (V) | |
| 25.04.2021 11:00 | Miločajac | 2 : 1 | Mladost 1925 | |
| 25.04.2021 16:30 | Mineral 2015 | 0 : 0 | Zvezda | |
| 25.04.2021 16:30 | Jedinstvo (D) | 2 : 3 | Lazac | |
| 25.04.2021 16:30 | Sloga Obrva | 2 : 0 | Bogutovačka Banja | |
| 25.04.2021 16:30 | Mladost 1981 | 0 : 1 | Jedinstvo (G) |
| 25.04.2021 16:00 | Zabrđe 1936 | 1 : 0 | Pobeda 1953 | |
| 25.04.2021 16:00 | Sloga 1952 | 2 : 0 | Mladost (R) | |
| 25.04.2021 16:00 | Radnički (K) | 3 : 2 | Borac (V) | |
| 25.04.2021 16:00 | Sloga 1945 | 4 : 1 | Jedinstvo (K) |
| 25.04.2021 16:30 | Rudar (P) | 4 : 1 | Napredak (St) | |
| 25.04.2021 16:30 | Jasenovo | 1 : 3 | Napredak (Sv) | |
| 25.04.2021 16:30 | Pomoravlje | 4 : 3 | Sloga | |
| 25.04.2021 16:30 | 15. Avgust 1950 | 5 : 4 | Rudar (S) |
| 25.04.2021 16:30 | Sloboda | 3 : 1 | Mladost (G) | |
| 25.04.2021 16:30 | Partizan | 6 : 0 | Sinđelić 1934 | |
| 25.04.2021 16:30 | Osaonica | 4 : 2 | Ursule | |
| 25.04.2021 16:30 | Jedinstvo | 4 : 1 | Zenit | |
| 25.04.2021 16:30 | Mladost (T) | 2 : 0 | Šantarovac |
| 25.04.2021 17:00 | Munja | 10 : 0 | Ljubinić | |
| 25.04.2021 17:00 | OFK Urovci | 0 : 2 | Sloga | |
| 25.04.2021 16:00 | Borac | 1 : 2 | Krtinska | |
| 25.04.2021 17:00 | Partizan | 0 : 1 | Pobednik | |
| 25.04.2021 17:00 | Skela | 3 : 0 | Rvati | |
| 25.04.2021 17:00 | Proleter | 3 : 2 | Belo Polje |
| 25.04.2021 16:00 | Kolubara (J) | 1 : 0 | OFK Stublenica | |
| 25.04.2021 11:00 | Proleter (B) | 2 : 0 | Šarbane | |
| 25.04.2021 11:00 | Omladinac (K) | 1 : 0 | Polet (T) | |
| 25.04.2021 16:00 | Ratkovac | 1 : 1 | Polet (DL) | |
| 25.04.2021 16:00 | Mladost (V) | 3 : 0 | Joševa | |
| 25.04.2021 16:00 | OFK Paljuvi | 1 : 1 | Crvena Jabuka | |
| 25.04.2021 16:00 | Zvizdar 2012 | 1 : 0 | Kalenić | |
| 25.04.2021 16:00 | Čučuge | 1 : 1 | Rudar 1945 |
| 25.04.2021 16:30 | Napredak (Č) | 2 : 0 | Omladinac | |
| 25.04.2021 16:30 | Proleter | 5 : 1 | Terekves | |
| 25.04.2021 16:30 | Napredak (BT) | 4 : 2 | Roham |
| 25.04.2021 11:00 | Stari drugari | 2 : 3 | Rakac Stave | |
| 25.04.2021 11:00 | Jadar 2013 | 6 : 0 | Polet | |
| 25.04.2021 11:00 | Komanice | 2 : 2 | Milenko Pavlović | |
| 25.04.2021 11:00 | Dračić 2018 | 1 : 1 | Popadić | |
| 25.04.2021 11:00 | Toplica | 1 : 0 | Rajac | |
| 25.04.2021 11:00 | Lukavac | 0 : 4 | Žabari | |
| 25.04.2021 11:00 | Mali korak | 1 : 3 | Junior Novo Naselje | |
| 25.04.2021 11:00 | Tešnjar | 1 : 0 | Mladost (L) |
| 25.04.2021 16:30 | Sušica 2012 | 2 : 3 | MB | |
| 25.04.2021 16:30 | Navalin | 1 : 2 | Badince | |
| 25.04.2021 16:30 | Todorovce | 1 : 3 | Mladost (B) |
| 25.04.2021 16:30 | Jasenovik 2018 | 0 : 2 | Radnički 2020 | |
| 25.04.2021 16:30 | Spartak | 2 : 5 | Mezgraja | |
| 25.04.2021 16:30 | Supovac | 0 : 0 | Sloga 1948 | |
| 25.04.2021 16:30 | Proleter | 7 : 0 | Rujnik |
| 25.04.2021 11:00 | OFK Sloga | 6 : 2 | Tempo | |
| 25.04.2021 11:00 | Rutevac | 2 : 4 | Polet (V) | |
| 25.04.2021 11:00 | Crvena zvezda | 6 : 0 | Borac |
| 25.04.2021 16:30 | Graničar | 2 : 1 | Hajduk | |
| 25.04.2021 16:30 | Slavija | 1 : 0 | Horgoš 1911 | |
| 25.04.2021 16:30 | Čoka | 2 : 1 | Jedinstvo | |
| 25.04.2021 16:30 | Tromedja | 0 : 5 | Šampion | |
| 25.04.2021 16:30 | Bačka | 3 : 1 | Tisa |
| 25.04.2021 16:00 | Omladinac | 0 : 1 | Petlić SD 026 | |
| 25.04.2021 16:00 | Badljevica | 0 : 2 | Vožd 2020 | |
| 25.04.2021 16:00 | Landol | 5 : 2 | Petrijevac | |
| 25.04.2021 16:00 | Lunjevac | 5 : 2 | Kolarac |
| 25.04.2021 16:00 | Proleter 1947 | 1 : 1 | Godomin | |
| 25.04.2021 16:00 | OFK Slavija | 0 : 9 | Jezava |
| 25.04.2021 17:00 | Belpos | 1 : 4 | Mladost (Z) | |
| 25.04.2021 17:00 | Skupljen 2013 | 3 : 1 | Mladost 2013 | |
| 25.04.2021 17:00 | Polet | 7 : 1 | Sparta | |
| 25.04.2021 11:00 | Torpedo | 1 : 7 | Bobovik | |
| 25.04.2021 11:00 | Sloga 1949 | 2 : 1 | Jedinstvo 2014 | |
| 25.04.2021 11:00 | Hajduk | 3 : 5 | Verko |
| 25.04.2021 16:30 | Tempo | 1 : 5 | Jedinstvo Stević | |
| 25.04.2021 16:30 | Pobeda | 3 : 1 | Omladinac 1927 | |
| 25.04.2021 16:30 | Glogonj | 3 : 1 | Unirea |
| 25.04.2021 16:00 | Kej | 8 : 0 | Gladijator | |
| 25.04.2021 16:00 | Vujan | 2 : 2 | Prijatelji | |
| 25.04.2021 16:00 | Lugovi | 4 : 2 | Gavrilo Princip | |
| 25.04.2021 13:00 | Budućnost | 2 : 1 | Planinac | |
| 25.04.2021 16:00 | Malba | 5 : 0 | OFK Remont 1959 | |
| 25.04.2021 16:00 | Mršinci | 2 : 1 | Čačak 94 |
| 25.04.2021 16:00 | Veliki Suvodol | 0 : 1 | Rongo Siti | |
| 25.04.2021 16:00 | Lokomotiva | 1 : 5 | Nišavac |
| 25.04.2021 17:00 | Bikovo | 1 : 2 | Lokomotiva | |
| 25.04.2021 17:00 | Palić | 1 : 2 | Vinogradar | |
| 25.04.2021 17:00 | Hajduk 1950 | 4 : 1 | Solid | |
| 25.04.2021 17:00 | Udarnik Višnjevac | 3 : 1 | Čantavir | |
| 25.04.2021 17:00 | OFK Mala Bosna 2015 | 2 : 1 | Žednik |
| 25.04.2021 17:00 | Krivanj | 2 : 1 | Soko | |
| 25.04.2021 17:00 | Bački Hajduk | 1 : 2 | Bačka 1945 | |
| 25.04.2021 17:00 | Borac (V) | 0 : 3 | Neštin | |
| 25.04.2021 17:00 | Proleter | 1 : 5 | Mladost (MB) | |
| 25.04.2021 17:00 | Naša Zvezda | 3 : 0 | Slavija |
| 25.04.2021 16:30 | Pričinović | 4 : 5 | Trešnjevka | |
| 25.04.2021 16:30 | PSK | 2 : 3 | OFK Letnjikovac 1983 | |
| 25.04.2021 16:30 | Šipurske livade | 5 : 2 | OFK Varna | |
| 25.04.2021 16:30 | Petrovac 74 | 1 : 3 | Vojvoda Stepa Stepanović | |
| 25.04.2021 16:30 | Mrovska | 3 : 1 | Dobrava |
| 25.04.2021 | Omladinac | 1 : 1 | Lunjevica | |
| 25.04.2021 | Jablanica | 3 : 1 | Majdan | |
| 25.04.2021 | Semedraž | 1 : 4 | Šumadija | |
| 25.04.2021 | Brezak | 1 : 0 | Velereč 94 | |
| 25.04.2021 | FC Stella Rossa | 4 : 1 | Šilopaj |
| 25.04.2021 16:30 | Velika Reka | 2 : 3 | Studenac | |
| 25.04.2021 16:30 | Prva Iskra | 1 : 0 | Jedinstvo (ZA) | |
| 25.04.2021 16:30 | Jelav | 2 : 4 | Jedinstvo (MZ) | |
| 25.04.2021 16:30 | 7. Juli | 4 : 3 | Sloga | |
| 25.04.2021 16:30 | Mladost | 3 : 0 | Borac | |
| 25.04.2021 16:30 | TE Gučevo | 3 : 2 | Antimon |
| 25.04.2021 16:30 | Pontes | 0 : 3 | Egeta | |
| 25.04.2021 16:30 | Omladinac | 0 : 1 | Mala Vrbica | |
| 25.04.2021 16:30 | Lokomotiva | : | Kladušnica | |
| 25.04.2021 16:30 | Rtkovo | 4 : 1 | Koča Anđelković |
| 25.04.2021 16:00 | Brezova | 1 : 0 | Radnički | |
| 25.04.2021 16:00 | Gorušica | 7 : 1 | Vrelo | |
| 25.04.2021 16:00 | Gradina | 2 : 2 | Jelica | |
| 25.04.2021 16:00 | Sloga | 2 : 3 | Bratstvo |
| 25.04.2021 16:30 | Mladost | 2 : 2 | Zadrugar Milkivit | |
| 25.04.2021 16:30 | Petlovača | 1 : 0 | Sloboda | |
| 25.04.2021 16:30 | Napredak | 5 : 1 | Sunrise Šabac | |
| 25.04.2021 16:30 | Lipolist | 0 : 3 | Milicionar | |
| 25.04.2021 16:30 | Omladinac 2013 (SL) | 5 : 0 | Partizan | |
| 25.04.2021 16:30 | Omladinac (BO) | 3 : 2 | Budućnost (ZM) | |
| 25.04.2021 16:30 | Torpedo 1924 | 5 : 3 | Budućnost (DO) |
| 25.04.2021 12:30 | Trešnjica | 1 : 1 | Knjaz | |
| 25.04.2021 13:30 | Plavi Tok | 2 : 1 | Dobrinjac | |
| 25.04.2021 16:30 | Gorobilje | 2 : 1 | Napredak | |
| 25.04.2021 16:30 | Glumač | 5 : 1 | Duškovci |
| 25.04.2021 16:30 | Pobeda | 1 : 2 | Jedinstvo | |
| 25.04.2021 16:30 | Tomislavci | 5 : 2 | Mladost Radost |
| 25.04.2021 16:00 | Palanka | 5 : 3 | Šumadija | |
| 25.04.2021 16:00 | Udarnik | 2 : 1 | Budućnost 1948 |
| 25.04.2021 16:00 | Mladost | 3 : 0 | Karadjordje | |
| 25.04.2021 16:00 | Omladinac | 0 : 1 | Jedinstvo |
| 25.04.2021 11:00 | Lepaja 2018 | 1 : 3 | Rad 1974 | |
| 25.04.2021 11:00 | Jastrebac 1979 | 0 : 6 | Sloga 1980 |
| 25.04.2021 16:30 | OFK Tamnič | 1 : 2 | Miloševo | |
| 25.04.2021 11:00 | Vrelo | 1 : 0 | OFK Sikole |
| 25.04.2021 16:30 | Mudrakovac | 2 : 2 | Naupare | |
| 25.04.2021 11:00 | Bukovica | 0 : 7 | Rasina | |
| 25.04.2021 11:00 | Polet | 3 : 0 | Pepeljevac 1947 | |
| 25.04.2021 16:30 | Konjuh | 2 : 2 | Gaglovo |
| 25.04.2021 11:00 | 10. februar | 0 : 2 | Toplica | |
| 25.04.2021 11:00 | Grkinja | 0 : 6 | Marina Kutina |
| 25.04.2021 16:30 | Gročanski fudbalski klub | 2 : 1 | OFK Mladost | |
| 25.04.2021 16:30 | Hajduk | 2 : 2 | Umčari |
| 25.04.2021 13:00 | Slemen | 2 : 0 | Mladost |
| 25.04.2021 14:00 | Velika Morava | 1 : 0 | Parcane | |
| 25.04.2021 16:30 | OFK Orašje 1960 | 5 : 3 | Mladi radnik | |
| 25.04.2021 14:00 | Stara Čaršija | 0 : 1 | Varvarin | |
| 25.04.2021 14:00 | Ratajac | 6 : 2 | Borjak 2012 |
| 25.04.2021 16:30 | Partizan | 8 : 0 | Proleter | |
| 25.04.2021 16:30 | Sloga | 2 : 3 | Borac |
| 25.04.2021 16:30 | Magnohrom | 4 : 0 | Milakovac 2018 | |
| 25.04.2021 11:00 | Biljanovac | 0 : 0 | Omladinac | |
| 25.04.2021 16:30 | BSK 2014 | 0 : 1 | Partizan | |
| 25.04.2021 11:00 | Stara Čaršija | 0 : 2 | Studen Vitez | |
| 25.04.2021 16:30 | Šumadija | 2 : 5 | Koštam Polje | |
| 25.04.2021 16:30 | Morava | 4 : 1 | Zgodačica |
| 25.04.2021 16:30 | Planinac | 2 : 2 | Sloga (S) | |
| 25.04.2021 16:30 | Jedinstvo (K) | 3 : 0 | Borac (S) | |
| 25.04.2021 16:30 | Car Uroš | 3 : 4 | Graničar | |
| 25.04.2021 16:30 | Polet | 4 : 3 | Fruškogorac | |
| 25.04.2021 16:30 | Sloga (K) | 2 : 3 | Borac (J) | |
| 25.04.2021 16:30 | 27. Oktobar | 1 : 0 | Donji Petrovci |
| 25.04.2021 11:00 | Vukona | 0 : 4 | Vrelo | |
| 25.04.2021 11:00 | Sloga (V) | 1 : 3 | Jedinstvo (M) | |
| 25.04.2021 11:00 | Tamnava | 0 : 6 | Gunjevac | |
| 25.04.2021 11:00 | Budućnost 1995 | 0 : 3 | Sovljak | |
| 25.04.2021 11:00 | Murgaš 2012 | 3 : 2 | Brgule | |
| 25.04.2021 11:00 | Dokmir | 2 : 2 | Kolubara (LP) |
| 25.04.2021 16:30 | Polet | 1 : 3 | Donja Mutnica | |
| 25.04.2021 16:30 | Železničar | 0 : 4 | Borac 1950 | |
| 25.04.2021 16:30 | BSK Buljane | 1 : 1 | ISK Izvor |
| 25.04.2021 16:30 | Heroj | 0 : 0 | Jedinstvo | |
| 25.04.2021 16:30 | Moravac | 2 : 0 | Razvitak | |
| 25.04.2021 16:30 | Budućnost | 4 : 0 | Potočac |
| 25.04.2021 16:30 | Jedinstvo Lemeš | 3 : 6 | Rastina 1918 | |
| 25.04.2021 16:30 | Dinamo (S) | 2 : 1 | Telečka |
| 25.04.2021 17:00 | Oniks | 2 : 3 | Dražmirovac | |
| 25.04.2021 17:00 | Trnava | 7 : 2 | Belica | |
| 25.04.2021 17:00 | Dobra Voda | 0 : 3 | GFK Strelište | |
| 25.04.2021 17:00 | OFK Dragoševac | 1 : 1 | Domaćin |
| 25.04.2021 11:00 | BSK 1924 | 1 : 5 | Šapine | |
| 25.04.2021 11:00 | Jedinstvo (S) | 5 : 1 | Stig (C) | |
| 25.04.2021 11:00 | Radnik (S) | 2 : 2 | Stig (MC) |
| 25.04.2021 16:30 | Janošik | 5 : 1 | Sloga | |
| 25.04.2021 16:30 | Dobrica | 3 : 6 | Banatul |
| 25.04.2021 16:30 | Pobeda | 1 : 2 | Hajduk | |
| 25.04.2021 16:30 | Vinogradar | 1 : 2 | Vitorul |
| 25.04.2021 17:00 | Vreoci | 2 : 4 | BSK | |
| 25.04.2021 17:00 | Sloga | 2 : 3 | Dimitrije Tucović | |
| 25.04.2021 17:00 | Proleter | 6 : 1 | Sloboda |
| 25.04.2021 17:00 | 20. Oktobar | 0 : 0 | Šumadinac | |
| 25.04.2021 17:00 | OFK Polet | 3 : 4 | Mladost | |
| 25.04.2021 17:00 | Bistrica | 3 : 0 | Mladi radnik |
| 25.04.2021 11:00 | Junkovac | 2 : 3 | Kalipolje | |
| 25.04.2021 11:00 | Krćevac 04 | 4 : 4 | Maskar | |
| 25.04.2021 11:00 | Jarmenovci | 0 : 1 | Gornja Trnava 1938 |
| 25.04.2021 16:00 | Udarnik 2015 | 0 : 0 | Vukan |
| 25.04.2021 11:00 | Rudar 1973 | 4 : 1 | Mladost | |
| 25.04.2021 11:00 | Radnik 2013 | 2 : 10 | ŠFU Derbi 2016 |
| 25.04.2021 11:00 | Kragujevac | 2 : 2 | Jovanovac | |
| 25.04.2021 16:30 | Bukorovac | 2 : 0 | Kremenac | |
| 25.04.2021 16:30 | Hajduk 1936 | 1 : 3 | Stanovo 1941 |
| 25.04.2021 16:00 | Pobeda | 1 : 3 | Metalac | |
| 25.04.2021 16:00 | Proleter 1932 | 3 : 4 | Napredak 1934 | |
| 25.04.2021 16:00 | Beli Orao | 1 : 1 | Vojvoda Milenko |
| 25.04.2021 16:00 | Mip Majdan | 2 : 4 | Sloga 1932 | |
| 25.04.2021 16:00 | Morava 1932 | 7 : 0 | Moravac 1933 | |
| 25.04.2021 16:00 | Sopot | 5 : 2 | Margum |
| 25.04.2021 16:30 | Borac (R) | 3 : 0 | Borac (VR) | |
| 25.04.2021 16:30 | Poletarac | 0 : 10 | Srem (SR) | |
| 25.04.2021 16:30 | Srem (SM) | 9 : 2 | Sloga | |
| 25.04.2021 16:30 | Planinac | 1 : 1 | OFK Bosut |
| 25.04.2021 11:00 | Sava | 1 : 0 | Mladost Svileuva | |
| 25.04.2021 11:00 | Galeb 1984 | 3 : 4 | Borac BTG | |
| 25.04.2021 11:00 | Miloš Pocerac | 0 : 4 | Korman | |
| 25.04.2021 11:00 | Dobrava Žabar 2020 | 5 : 1 | Rudar |
| 25.04.2021 11:00 | Maovi MH | 4 : 2 | Mladost | |
| 25.04.2021 11:00 | Zablaće | 5 : 1 | Bojić | |
| 25.04.2021 11:00 | Pocerina | 1 : 2 | Metlić | |
| 25.04.2021 11:00 | Jedinstvo | 1 : 6 | Dumača |
| 25.04.2021 11:00 | Sloga | 2 : 0 | Culjković | |
| 25.04.2021 11:00 | Roma - Odžino selo | 4 : 1 | Napredak |
| 25.04.2021 16:00 | Budućnost | 1 : 5 | Mladost | |
| 25.04.2021 16:00 | Sloga | 0 : 2 | Jedinstvo | |
| 25.04.2021 16:00 | BSK | 0 : 3 | Polet |
| 25.04.2021 10:00 | Mlava (R) | 0 : 1 | Mladost (K) | |
| 25.04.2021 10:00 | Homoljac | 7 : 1 | Laznica | |
| 25.04.2021 10:00 | Budućnost (M) | 2 : 2 | Vrelo 1971 | |
| 25.04.2021 10:00 | Best Sige | 0 : 1 | Bliznak-Medveđica |
| 25.04.2021 16:00 | Kačer | 2 : 0 | Sloga | |
| 25.04.2021 16:00 | Nepričava | 2 : 1 | Babajić |
| 25.04.2021 16:30 | Mladost (B) | 1 : 0 | Paskovac | |
| 25.04.2021 16:30 | Jadar | 3 : 2 | Granit |
| 25.04.2021 16:00 | Radnički (P) | 3 : 0 | Mirko Tomić | |
| 25.04.2021 16:00 | Stiški Kurjak | 2 : 0 | Sloga-Top |
| 25.04.2021 16:30 | Mladi radnik | 3 : 0 | Napredak |
| 25.04.2021 11:00 | OFK Napredak 1933 | 1 : 3 | Stojan Lazarac |
| 25.04.2021 11:00 | Padež | 1 : 0 | Grkljane | |
| 25.04.2021 11:00 | Dedina | 5 : 0 | Mladost 2015 | |
| 25.04.2021 11:00 | Dvorane | 1 : 1 | Kruševica |
| 25.04.2021 11:00 | Prvi srpski Ustanak II | 0 : 4 | Misača | |
| 25.04.2021 11:00 | Ranilović 1970 | 1 : 2 | Tulež |
| 25.04.2021 16:30 | Borac | 0 : 0 | Sinđelić | |
| 25.04.2021 16:30 | OFK Bingula | 0 : 1 | Jedinstvo (M) | |
| 25.04.2021 16:30 | Napredak | 0 : 1 | OFK Bačinci | |
| 25.04.2021 16:30 | Graničar | 5 : 1 | Jedinstvo (Lj) |
| 25.04.2021 16:30 | Kupinovo | 5 : 2 | Mladost 1935 | |
| 25.04.2021 16:30 | Hajduk 1932 | 11 : 0 | Sloven | |
| 25.04.2021 16:30 | Vitez | 2 : 9 | Lovac |
| 25.04.2021 17:00 | PSS-192 | 2 : 3 | Morava |
| 25.04.2021 14:00 | OFK Petrovac | 3 : 1 | Rudar | |
| 25.04.2021 18:00 | OFK Titograd | 0 : 2 | Budućnost | |
| 25.04.2021 19:00 | Podgorica | 1 : 0 | Iskra | |
| 25.04.2021 16:00 | Sutjeska | 0 : 0 | Jezero | |
| 25.04.2021 17:00 | Dečić | 3 : 1 | Zeta |
| 25.04.2021 20:00 | Aston Villa | 2 : 2 | West Bromwich Albion | |
| 25.04.2021 15:00 | Leeds United | 0 : 0 | Manchester United | |
| 25.04.2021 13:00 | Wolverhampton | 0 : 4 | Burnley |
| 25.04.2021 14:00 | Bristol City | 2 : 3 | Luton Town | |
| 25.04.2021 13:00 | Reading | 2 : 2 | Swansea City |
| 25.04.2021 21:00 | Athletic Club | 2 : 1 | Atletico Madrid | |
| 25.04.2021 18:30 | Celta Vigo | 2 : 1 | Osasuna | |
| 25.04.2021 14:00 | Huesca | 0 : 2 | Getafe | |
| 25.04.2021 18:30 | Sevilla | 2 : 1 | Granada | |
| 25.04.2021 16:15 | Villarreal | 1 : 2 | Barcelona |
| 25.04.2021 15:30 | RB Leipzig | 2 : 0 | Stuttgart | |
| 25.04.2021 18:00 | Borussia M'gladbach | 5 : 0 | Arminia |
| 25.04.2021 17:05 | Angers SCO | 0 : 1 | Monaco | |
| 25.04.2021 15:00 | Lens | 2 : 1 | Nîmes | |
| 25.04.2021 15:00 | Lorient | 4 : 1 | Bordeaux | |
| 25.04.2021 21:00 | Olympique Lyonnais | 2 : 3 | Lille | |
| 25.04.2021 13:00 | Nice | 3 : 1 | Montpellier | |
| 25.04.2021 15:00 | Rennes | 5 : 1 | Dijon | |
| 25.04.2021 15:00 | Strasbourg | 1 : 2 | Nantes |
| 25.04.2021 20:45 | Atalanta | 5 : 0 | Bologna | |
| 25.04.2021 15:00 | Fiorentina | 1 : 1 | Juventus | |
| 25.04.2021 18:00 | Cagliari | 3 : 2 | Roma | |
| 25.04.2021 12:30 | Benevento | 2 : 4 | Udinese | |
| 25.04.2021 15:00 | Internazionale | 1 : 0 | Hellas Verona |
| 25.04.2021 15:30 | Crvena zvezda | 0 : 4 | Spartak |
| 25.04.2021 13:00 | ŽGFK Lavice Dubočica | 1 : 4 | Mačva | |
| 25.04.2021 13:00 | Majdanpek | 4 : 1 | Loznica | |
| 25.04.2021 13:00 | ŽFU Zvezda B 2018 | 11 : 0 | Heroj Polet |
| 25.04.2021 13:00 | Požega | 0 : 3 | Borac | |
| 25.04.2021 15:00 | Slatke male | 2 : 0 | Kraljica Marija | |
| 25.04.2021 12:00 | Jedinstvo | 7 : 0 | Una Fortuna | |
| 25.04.2021 12:30 | Šabac | 0 : 7 | Karađorđe |
| 25.04.2021 16:30 | Vojvodina | 1 : 0 | TSC | |
| 25.04.2021 13:00 | Zemun | 1 : 5 | Požarevac |
| 25.04.2021 11:00 | Internacional | 3 : 2 | Spartak ŽK | |
| 25.04.2021 13:00 | Napredak | 0 : 2 | Čukarički | |
| 25.04.2021 11:00 | OFK Beograd | 1 : 1 | Radnički 1923 | |
| 25.04.2021 11:00 | Partizan | 1 : 3 | Vojvodina |
| 25.04.2021 10:00 | Radnički 1912 | 1 : 1 | Inđija | |
| 25.04.2021 10:00 | OFK Bačka | 3 : 0 | Omladinac |
| 25.04.2021 10:00 | RFK Novi Sad 1921 | 1 : 2 | Petrika | |
| 25.04.2021 10:00 | Bačka 1901 | 5 : 1 | Tisa Njerš | |
| 25.04.2021 10:00 | Hajduk 1912 | 3 : 2 | Petar Puača |
| 25.04.2021 10:00 | Radnički (SM) | 1 : 4 | Radnički (NP) |
| 25.04.2021 16:00 | Morava (VP) | 0 : 2 | Budućnost Krušik 2014 | |
| 25.04.2021 13:30 | GFK Sloboda | 5 : 0 | Šumadija (A) | |
| 25.04.2021 11:00 | Metalac | 0 : 2 | Borac 1926 | |
| 25.04.2021 12:30 | Jedinstvo (Ub) | 0 : 1 | Šabac Sunrise | |
| 25.04.2021 16:00 | Radnički (V) | 6 : 1 | Sloga (P) | |
| 25.04.2021 13:00 | Javor Matis | 5 : 0 | Loznica |
| 25.04.2021 | OFK Topličanin | 3 : 0 | OFK Lugomir | |
| 25.04.2021 | GFK Jagodina | 11 : 1 | Radnik |
| 25.04.2021 11:00 | Zvižd | 0 : 6 | Karađorđe |
| 25.04.2021 11:00 | Šumadija | 10 : 1 | OFK Urovci |
| 25.04.2021 16:00 | Torlak | 2 : 0 | Sinđelić | |
| 25.04.2021 16:30 | BASK | 4 : 4 | IMT 2 | |
| 25.04.2021 17:00 | Bežanija | 2 : 1 | Železnik 1930 |
| 25.04.2021 09:00 | Balkan | 0 : 2 | IM Rakovica | |
| 25.04.2021 11:00 | Mladenovac | 1 : 7 | Crvenka |
| 25.04.2021 13:00 | Rojkovac | 3 : 0 | Poštar 1930 |
| 25.04.2021 14:00 |