| 16.05.2021 17:00 | Zrinjski | 3 : 1 | Krupa | |
| 16.05.2021 17:00 | Željezničar | 1 : 2 | Borac | |
| 16.05.2021 17:00 | Tuzla City | 1 : 1 | Velež | |
| 16.05.2021 17:00 | Sloboda | 1 : 1 | Široki Brijeg | |
| 16.05.2021 17:00 | Mladost | 0 : 0 | Sarajevo | |
| 16.05.2021 17:00 | Radnik | 1 : 0 | Olimpik |
| 16.05.2021 17:00 | Borac | 3 : 2 | Tisa |
| 16.05.2021 17:00 | Železničar (L) | 2 : 2 | Budućnost (A) | |
| 16.05.2021 17:00 | GFK Sloboda | 4 : 2 | Mladi radnik 1926 |
| 16.05.2021 16:30 | Jedinstvo | 5 : 3 | Studentski grad | |
| 16.05.2021 16:30 | Zvezdara | 2 : 0 | Crvena zvezda |
| 16.05.2021 17:00 | Vlasina | 0 : 0 | OFK Sinđelić | |
| 16.05.2021 17:00 | Radnički (S) | 3 : 0 | Dunav | |
| 16.05.2021 11:00 | SFS Borac | 1 : 0 | Timok 1919 | |
| 16.05.2021 17:00 | Budućnost (P) | 2 : 1 | Pčinja | |
| 16.05.2021 11:00 | Car Konstantin | 3 : 2 | Jedinstvo (P) | |
| 16.05.2021 17:00 | Župa | 0 : 2 | Timočanin | |
| 16.05.2021 17:00 | Rembas | 2 : 0 | Radan |
| 16.05.2021 17:00 | Šumadija (T) | 1 : 0 | Radnik | |
| 16.05.2021 17:00 | Novi Pazar 1928 | 4 : 2 | Borac | |
| 16.05.2021 17:00 | Korićani | 2 : 1 | Proleter | |
| 16.05.2021 17:00 | Budućnost | 0 : 0 | Real |
| 16.05.2021 17:00 | Borac (Ž) | 0 : 4 | OFK Mihajlovac | |
| 16.05.2021 17:00 | Sloga (M) | 0 : 6 | Borac 1932 | |
| 16.05.2021 17:00 | Petar Dobrnjac | 1 : 7 | Pomoravlje | |
| 16.05.2021 17:00 | Rudar (S) | 6 : 2 | Jasenica 2017 | |
| 16.05.2021 17:00 | OFK Aranđelovac 1979 | 2 : 5 | RSK |
| 16.05.2021 11:00 | Jedinstvo Putevi | 2 : 2 | Sloga (BB) | |
| 16.05.2021 17:00 | Zlatar | 0 : 2 | Prijevor | |
| 16.05.2021 17:00 | Polimlje | 0 : 3 | Polet (T) | |
| 16.05.2021 11:00 | Polet (Lj) | 4 : 3 | Jasen | |
| 16.05.2021 17:00 | Omladinac | 2 : 0 | Sloboda (Č) |
| 16.05.2021 17:00 | OFK Divci | 6 : 0 | Drina | |
| 16.05.2021 17:00 | Mladost (DD) | 2 : 1 | Jedinstvo Vladimirci 1924 | |
| 16.05.2021 17:00 | Rađevac | 3 : 2 | Borac (L) | |
| 16.05.2021 17:00 | Vrelo Sport | 0 : 0 | Sloga (B) | |
| 16.05.2021 17:00 | Mladost (P) | 4 : 0 | Spartak 1924 |
| 16.05.2021 17:00 | Tavankut | 1 : 2 | Krila Krajine | |
| 16.05.2021 17:00 | Vojvodina (BG) | 4 : 0 | Hercegovac |
| 16.05.2021 17:00 | Crvena zvezda | 4 : 1 | Radnički (S) | |
| 16.05.2021 17:00 | Banat | 4 : 3 | Naftagas | |
| 16.05.2021 17:00 | Borac | 1 : 0 | Radnički (K) | |
| 16.05.2021 17:00 | Mladost | 5 : 2 | Jedinstvo (V) |
| 16.05.2021 17:00 | Podunavac | 1 : 0 | Jadran | |
| 16.05.2021 17:00 | Sloboda | 2 : 0 | Sloga (T) | |
| 16.05.2021 17:00 | Jugović | 1 : 3 | Borac | |
| 16.05.2021 17:00 | Sremac Vojka | 2 : 1 | Sloga (E) |
| 16.05.2021 17:00 | Jedinstvo (M) | 3 : 1 | Levač | |
| 16.05.2021 17:00 | Temnić 1924 | 0 : 3 | Sloga (D) | |
| 16.05.2021 17:00 | Bošnjane | 1 : 2 | Juhor | |
| 16.05.2021 17:00 | Moravac 2015 | 2 : 4 | Jedinstvo 1936 |
| 16.05.2021 11:00 | Jedinstvo (P) | 2 : 1 | Lužnica | |
| 16.05.2021 17:00 | OFK Slatina | 5 : 2 | Brodoremont | |
| 16.05.2021 17:00 | Hajduk Veljko | 2 : 0 | Balkanski | |
| 16.05.2021 17:00 | Rajko Mitić | 1 : 2 | Bor 1919 |
| 16.05.2021 17:00 | Naisus 1977 | 3 : 9 | Naša krila 1936 | |
| 16.05.2021 11:00 | Malošište | 5 : 6 | Pukovac | |
| 16.05.2021 17:00 | Delijski Vis | 0 : 3 | OFK Brzi Brod | |
| 16.05.2021 17:00 | Rudar | 3 : 3 | Morava | |
| 16.05.2021 17:00 | Bukovik | 3 : 1 | OFK Niš | |
| 16.05.2021 17:00 | Jedinstvo (GM) | 2 : 2 | OFK Napredak 1929 | |
| 16.05.2021 17:00 | Orljane | 3 : 1 | Zemljoradnik |
| 16.05.2021 17:00 | Alakince | 1 : 1 | Jablanica | |
| 16.05.2021 17:00 | Vranjska Banja | 4 : 2 | Jedinstvo (GS) |
| 16.05.2021 16:30 | Komgrap | 0 : 1 | Turbina | |
| 16.05.2021 16:30 | Vrčin | 1 : 2 | Vinča | |
| 16.05.2021 16:30 | Budućnost (Z) | 0 : 2 | Srem | |
| 16.05.2021 16:30 | Dunav | 3 : 0 | Poštar Zvezdara | |
| 16.05.2021 11:00 | Prva iskra | 1 : 1 | Torlak | |
| 16.05.2021 16:30 | Mladost (C) | 1 : 2 | BSK 1926 |
| 16.05.2021 17:00 | Osnić | 5 : 1 | Kosovo | |
| 16.05.2021 17:00 | Velika Jasikova | 2 : 2 | Radnički 1946 | |
| 16.05.2021 17:00 | Trebič | 3 : 2 | Rudar (P) | |
| 16.05.2021 13:00 | Graničar | 1 : 0 | OFK Rtanj | |
| 16.05.2021 17:00 | Omladinac | 2 : 1 | Rudar Vrška Čuka |
| 16.05.2021 17:00 | Mačkovac | 8 : 0 | Ribnik | |
| 16.05.2021 17:00 | FUD | 2 : 0 | Žabare | |
| 16.05.2021 17:00 | Gradina | 4 : 0 | Mladost (T) | |
| 16.05.2021 17:00 | Kupci | 5 : 3 | 13. April | |
| 16.05.2021 17:00 | Donji Kopaonik | 4 : 3 | Mladost (DK) | |
| 16.05.2021 17:00 | Sloga (Ć) | 3 : 4 | Vinogradar | |
| 16.05.2021 17:00 | Sloga (L) | 3 : 1 | Sloga (D) |
| 16.05.2021 17:00 | Sremac | 6 : 2 | LSK | |
| 16.05.2021 17:00 | Sloga | 2 : 3 | Ljukovo | |
| 16.05.2021 17:00 | Napredak | 1 : 2 | Hajduk (V) | |
| 16.05.2021 17:00 | BSK | 1 : 1 | Borac (M) | |
| 16.05.2021 17:00 | Donji Srem 2015 | 11 : 0 | PSK |
| 16.05.2021 17:00 | Jugoslavija | 1 : 0 | Budućnost (A) | |
| 16.05.2021 17:00 | Dolina | 1 : 4 | BAK | |
| 16.05.2021 17:00 | Strela | 4 : 1 | Stari Tamiš | |
| 16.05.2021 17:00 | Radnički (B) | 1 : 8 | Sloga (BNS) | |
| 16.05.2021 17:00 | Crvena zvezda | 3 : 0 | Potporanj | |
| 16.05.2021 17:00 | Hajdučica | 1 : 0 | Polet (Id) | |
| 16.05.2021 17:00 | Banat (I) | 2 : 3 | Spartak 1911 |
| 16.05.2021 17:00 | Kordun | 2 : 1 | Zadrugar | |
| 16.05.2021 17:00 | Borac 46 | 3 : 2 | SU Stanišić 1920 | |
| 16.05.2021 17:00 | Budućnost (G) | 2 : 0 | Radnički 1918 | |
| 16.05.2021 17:00 | Rusin | 3 : 0 | BSK | |
| 16.05.2021 17:00 | Omladinac | 1 : 0 | Tvrđava | |
| 16.05.2021 17:00 | Maglić | 1 : 2 | Polet | |
| 16.05.2021 17:00 | Kulpin | 1 : 0 | Slavija |
| 16.05.2021 17:00 | Jadran | 5 : 0 | Budućnost | |
| 16.05.2021 17:00 | Đurđin | 3 : 1 | Obilić | |
| 16.05.2021 17:00 | Senta | 5 : 0 | Tornjoš | |
| 16.05.2021 17:00 | Sutjeska | 2 : 3 | Preporod | |
| 16.05.2021 17:00 | Iskra | 1 : 0 | Proleter (Nj) |
| 16.05.2021 17:00 | Radnički 1911 | 0 : 1 | MSK | |
| 16.05.2021 17:00 | Polet | 2 : 3 | Vojvodina (B) | |
| 16.05.2021 17:00 | Tamiš | 1 : 4 | Potisje | |
| 16.05.2021 17:00 | Borac | 6 : 0 | Mladost (L) | |
| 16.05.2021 17:00 | Vojvodina (NM) | 2 : 2 | Crvena zvezda | |
| 16.05.2021 17:00 | 2. Oktobar | 4 : 0 | Lehel | |
| 16.05.2021 17:00 | Mladost (BD) | 4 : 0 | Rusanda |
| 16.05.2021 17:00 | Mladi borac | 2 : 0 | Polet | |
| 16.05.2021 17:00 | Mladi radnik 1940 | 3 : 1 | Bačinac | |
| 16.05.2021 17:00 | Sloga (L) | 3 : 1 | Osipaonica | |
| 16.05.2021 17:00 | Crvena zvezda | 4 : 1 | Bresje Superior | |
| 16.05.2021 17:00 | Podunavac | 0 : 2 | SASK | |
| 16.05.2021 17:00 | Sloga (M) | 1 : 1 | Radnik (SP) | |
| 16.05.2021 17:00 | Pobeda | 4 : 0 | Budućnost |
| 16.05.2021 17:00 | Lokomotiva | 1 : 0 | Prvi srpski ustanak | |
| 16.05.2021 17:00 | Marjan (K) | 5 : 1 | Sloga (Z) | |
| 16.05.2021 17:00 | Plaskovac | 1 : 2 | Šumadinac (S) | |
| 16.05.2021 17:00 | ŽSK | 1 : 0 | Partizan (BB) | |
| 16.05.2021 17:00 | Omladinac | 5 : 3 | Vinča | |
| 16.05.2021 17:00 | Trnava | 1 : 2 | Grizli ML | |
| 16.05.2021 17:00 | Banja 1957 | 2 : 2 | Šumadinac 1913 |
| 16.05.2021 16:30 | Šumadinac | 1 : 1 | Sinđelić 2012 | |
| 16.05.2021 16:00 | 011 | 5 : 1 | Borac (P) | |
| 16.05.2021 16:30 | PKB Kovilovo | 4 : 2 | Postar 1930 | |
| 16.05.2021 16:30 | Umka | 3 : 0 | Institut | |
| 16.05.2021 16:30 | Heroj Polet | 3 : 2 | Hajduk | |
| 16.05.2021 16:30 | Posavac Tišma | 2 : 1 | PKB (PS) | |
| 16.05.2021 16:30 | Balkan Mirijevo | 1 : 0 | Borac (O) |
| 16.05.2021 16:30 | Strelac | 7 : 1 | Mladi borac | |
| 16.05.2021 16:30 | Omladinac | 1 : 1 | Vranić | |
| 16.05.2021 16:30 | Jedinstvo | 2 : 3 | Radnički | |
| 16.05.2021 16:30 | Zvezda | 8 : 0 | Polet | |
| 16.05.2021 16:30 | OFK Borac | 0 : 0 | Rojkovac | |
| 16.05.2021 16:30 | OFK Zabrežje | 1 : 4 | Lisović 1977 | |
| 16.05.2021 16:30 | OFK Budućnost | 6 : 1 | Duboko |
| 16.05.2021 16:30 | Šumadija 1962 | 4 : 1 | SUF Dubona | |
| 16.05.2021 16:30 | Dunavac | 3 : 1 | SUF Kovačevac 1956 | |
| 16.05.2021 16:30 | Zuce 2019 | 3 : 0 | Kosmajac | |
| 16.05.2021 16:30 | Ivanča | 0 : 1 | Zaklopača | |
| 16.05.2021 16:30 | Rabrovac | 0 : 1 | Pudarci | |
| 16.05.2021 10:00 | Kaluđerica 1969 | 6 : 0 | Velika Krsna |
| 16.05.2021 17:30 | Hajduk | 1 : 1 | Titel | |
| 16.05.2021 17:30 | Bačka (B) | 2 : 0 | Jedinstvo | |
| 16.05.2021 17:30 | Tatra | 5 : 1 | Susek | |
| 16.05.2021 17:30 | Bačka 1923 | 1 : 8 | Veternik | |
| 16.05.2021 17:30 | Petrovaradin | 0 : 0 | Slavija | |
| 16.05.2021 17:30 | ŽSK | 3 : 1 | Fruškogorac |
| 16.05.2021 17:00 | Mladost | 2 : 4 | Polet | |
| 16.05.2021 11:00 | Ključ | 1 : 2 | Zlot | |
| 16.05.2021 17:00 | Radnički | 2 : 1 | Rudna Glava |
| 16.05.2021 17:00 | Maršić | 3 : 2 | Kolonija | |
| 16.05.2021 17:00 | Šumadija 1934 | 0 : 0 | Kutlovo | |
| 16.05.2021 17:00 | OFK Bagremar | 5 : 1 | Jedinstvo | |
| 16.05.2021 17:00 | 21. oktobar | 0 : 8 | Sloga (D) | |
| 16.05.2021 17:00 | Sloboda (G) | 0 : 5 | Zastava | |
| 16.05.2021 17:00 | Slavija | 2 : 2 | Šumadinac KG | |
| 16.05.2021 17:00 | Srbija | 4 : 1 | Pobeda 1926 |
| 16.05.2021 17:00 | Mladost (L) | 2 : 2 | Vulkan 1963 | |
| 16.05.2021 17:00 | Planinac 1933 | 6 : 4 | Radnički 1936 | |
| 16.05.2021 17:00 | Palilulac | 0 : 3 | Stevan Nešticki | |
| 16.05.2021 17:00 | Aluminjum | 8 : 1 | Mladost (DK) | |
| 16.05.2021 17:00 | Čegar 2013 | 2 : 2 | Sloboda | |
| 16.05.2021 17:00 | Crvena zastava | 0 : 4 | Omladinac | |
| 16.05.2021 17:00 | Čegar 1946 | 3 : 2 | Morava |
| 16.05.2021 17:00 | Napredak 1936 | 2 : 1 | Sirakovo | |
| 16.05.2021 17:00 | Sloga (L) | 4 : 3 | Mlava (ML) | |
| 16.05.2021 17:00 | Obilić | 1 : 1 | Borac (K) | |
| 16.05.2021 17:00 | Napredak Simićevo | 3 : 0 | Trgovački | |
| 16.05.2021 17:00 | Omladinac (Š) | 3 : 0 | Mladost (B) | |
| 16.05.2021 17:00 | Železničar | 1 : 3 | Integral | |
| 16.05.2021 17:00 | Budućnost (V) | 1 : 1 | Vihor |
| 16.05.2021 17:00 | Radnički 1947 | 0 : 1 | Doljevac | |
| 16.05.2021 17:00 | Baličevac | 2 : 2 | Radnički 1924 | |
| 16.05.2021 17:00 | OFK Rutevac 1908 | 0 : 3 | Jastrebac | |
| 16.05.2021 17:00 | Moravac (ZT) | 2 : 0 | Elid |
| 16.05.2021 17:30 | Granit | 0 : 4 | Karađorđe | |
| 16.05.2021 17:30 | Mataruge | 2 : 1 | Rudar | |
| 16.05.2021 17:30 | Popovići Vrnjci | 0 : 7 | Budućnost | |
| 16.05.2021 17:30 | Tavnik | 7 : 0 | Mladost (V) | |
| 16.05.2021 17:30 | Jedinstvo 2017 | 5 : 2 | Gruža | |
| 16.05.2021 17:30 | Napredak | 1 : 2 | Ibar | |
| 16.05.2021 17:30 | Kraljevo Hajduk | 1 : 3 | Ribnica |
| 16.05.2021 17:00 | Morava (R) | 0 : 1 | Juhor (G) | |
| 16.05.2021 17:00 | Kolare | 3 : 2 | Budućnost (M) | |
| 16.05.2021 17:00 | Partizan | 4 : 0 | Resavac | |
| 16.05.2021 17:00 | Orlovi | 6 : 0 | Mladost (K) | |
| 16.05.2021 17:00 | Napredak | 3 : 2 | Rudar | |
| 16.05.2021 17:00 | OFK Juhor 2016 | 3 : 0 | Sloga | |
| 16.05.2021 17:00 | Dragocvet | 3 : 1 | Mladost (J) |
| 16.05.2021 17:00 | Iskra | 3 : 5 | OFK Jabučje | |
| 16.05.2021 17:00 | ZSK | 1 : 0 | Kolubara 2 | |
| 16.05.2021 17:00 | Banjani | 1 : 0 | OFK Senjak | |
| 16.05.2021 17:00 | Trlić | 0 : 1 | Pambukovica |
| 16.05.2021 17:00 | Kumarevo 65 | 5 : 2 | Vučje | |
| 16.05.2021 11:00 | Bratstvo | 3 : 0 | Gradac | |
| 16.05.2021 17:00 | Bobište | 4 : 0 | Progres | |
| 16.05.2021 17:00 | Umac | 5 : 2 | Donja Lomnica | |
| 16.05.2021 17:00 | OFK Brza | 0 : 1 | Polet |
| 16.05.2021 17:00 | Šumadija | 1 : 3 | BSK | |
| 16.05.2021 17:00 | OFK Morava | 3 : 2 | Milanovo | |
| 16.05.2021 17:00 | Real | 2 : 1 | Sloboda | |
| 16.05.2021 17:00 | Plantaža | 5 : 0 | Železničar | |
| 16.05.2021 17:00 | Moravac | 0 : 3 | Mladi borac | |
| 16.05.2021 17:00 | Sloga | 3 : 1 | Mladost 1959 |
| 16.05.2021 17:00 | Sečica | 2 : 3 | Prvi partizan | |
| 16.05.2021 17:00 | Avijatičar Vranjani | 1 : 4 | Savinac | |
| 16.05.2021 17:00 | Čajetina | 1 : 0 | Višesava | |
| 16.05.2021 17:00 | Kotroman | 1 : 0 | Perućac | |
| 16.05.2021 17:00 | Jedinstvo | 2 : 1 | Polet | |
| 16.05.2021 17:00 | Omladinac | 3 : 2 | Bakionica | |
| 16.05.2021 17:00 | Ježevica | 3 : 1 | Lazarica |
| 16.05.2021 16:00 | Prilike | 2 : 3 | Dragačevo | |
| 16.05.2021 16:00 | Jedinstvo | 0 : 3 | Morava | |
| 16.05.2021 11:00 | Rakova | 2 : 1 | Ozremica |
| 16.05.2021 16:00 | Mladost (P) | 1 : 2 | Jedinstvo (K) | |
| 16.05.2021 16:00 | Donja Vrbava | 3 : 0 | Backovac Junajted | |
| 16.05.2021 16:00 | Ozrem PMH | 5 : 3 | Orlovac | |
| 16.05.2021 16:00 | Zadrugar | 7 : 1 | Rudar | |
| 16.05.2021 16:00 | Napredak | 3 : 1 | Jedinstvo (GG) |
| 16.05.2021 17:00 | Sloga | 3 : 0 | Mladost | |
| 16.05.2021 17:00 | Napredak | 1 : 2 | Vladimir Durković | |
| 16.05.2021 17:00 | Pobeda | 0 : 3 | Željuša | |
| 16.05.2021 17:00 | Spartak | 4 : 1 | Zadrugar |
| 16.05.2021 17:00 | Karađorđe | 2 : 4 | Duško | |
| 16.05.2021 17:00 | Majur | 1 : 0 | Drina | |
| 16.05.2021 17:00 | Sloga (LŠ) | 5 : 1 | Mladost | |
| 16.05.2021 17:00 | Mladi borac | 2 : 1 | Rudar | |
| 16.05.2021 17:00 | Cer (JL) | 4 : 0 | Hajduk Stanko | |
| 16.05.2021 11:00 | Vidojevica | 2 : 0 | Gučevo 1929 | |
| 16.05.2021 17:00 | Sloga (KR) | 0 : 3 | Cer (PE) | |
| 16.05.2021 17:00 | Podrinje | 5 : 1 | Jedinstvo |
| 16.05.2021 16:30 | FSU Južna pruga | 0 : 2 | Čelik | |
| 16.05.2021 16:30 | Vihor | 2 : 1 | BSK Bujanovac | |
| 16.05.2021 16:30 | Pavlovac | 5 : 1 | Mladost (B) | |
| 16.05.2021 16:30 | Trnovac | 8 : 1 | Mladost (S) | |
| 16.05.2021 16:30 | Levosoje | 1 : 7 | Lugina |
| 16.05.2021 00:00 | Moravac | 3 : 1 | Morava |
| 16.05.2021 17:00 | Omladinac (U) | 3 : 5 | Kamenorezac 76 | |
| 16.05.2021 17:00 | Župski biseri | 4 : 1 | Beli Orlovi | |
| 16.05.2021 17:00 | 14. Oktobar | 2 : 0 | Gradac | |
| 16.05.2021 17:00 | Vinogradar | 3 : 0 | Rubin |
| 16.05.2021 17:00 | Polet | 6 : 2 | Borac (VG) | |
| 16.05.2021 17:00 | Karaš (J) | 0 : 0 | Omladinac | |
| 16.05.2021 17:00 | Vulturul | 8 : 0 | Dunav | |
| 16.05.2021 17:00 | Partizan (K) | 3 : 2 | Banat (D) | |
| 16.05.2021 17:00 | Karaš (K) | 4 : 1 | Ratar | |
| 16.05.2021 17:00 | Ševac | 3 : 4 | Borac (VS) |
| 16.05.2021 17:00 | Borac (P) | 2 : 1 | Jedinstvo (D) | |
| 16.05.2021 17:00 | Omladinac (D) | 8 : 0 | Kolonija | |
| 16.05.2021 17:00 | Mladost (V) | 3 : 1 | BSK Bavanište |
| 16.05.2021 17:00 | Fruškogorac | 1 : 1 | ČSK | |
| 16.05.2021 17:00 | Napredak | 3 : 3 | Polet | |
| 16.05.2021 17:00 | OFK Brestač | 0 : 3 | Krušedol | |
| 16.05.2021 17:00 | Kameni | 0 : 4 | Jedinstvo | |
| 16.05.2021 17:00 | Sremac | 4 : 0 | Srem | |
| 16.05.2021 17:00 | Mladost | 2 : 0 | Graničar | |
| 16.05.2021 17:00 | Dunav | 0 : 2 | Šumar | |
| 16.05.2021 17:00 | Radnički | 3 : 1 | Hrtkovci |
| 16.05.2021 17:00 | Jedinstvo | 1 : 1 | Graničar 1924 | |
| 16.05.2021 17:00 | OFK Zeka Buljubaša | 5 : 0 | Jednota | |
| 16.05.2021 17:00 | Zmaj | 6 : 4 | Erdevik 2017 | |
| 16.05.2021 17:00 | Fruškogorac | 0 : 2 | OFK Bikić | |
| 16.05.2021 17:00 | Sremac (B) | : | Obilić 1993 | |
| 16.05.2021 17:00 | Sremac (J) | 4 : 0 | Sloga | |
| 16.05.2021 17:00 | Graničar (K) | 5 : 0 | Sloboda | |
| 16.05.2021 10:00 | Fruška Gora | 3 : 1 | Trgovački |
| 16.05.2021 17:00 | Bilećanin | 2 : 0 | OFK Stajićevo | |
| 16.05.2021 17:00 | OFK Gradnulica | 6 : 0 | Zlatica | |
| 16.05.2021 17:00 | Zadrugar | 0 : 1 | ŽFK Banat Bagljaš | |
| 16.05.2021 17:00 | Tisa 1933 | 3 : 2 | Naftagas |
| 16.05.2021 11:00 | Mladost (R) | 0 : 3 | Mladi rudar | |
| 16.05.2021 17:00 | Venčani | 3 : 2 | Kopljari | |
| 16.05.2021 17:00 | Radoje Domanović | 0 : 0 | Trešnjevica | |
| 16.05.2021 11:00 | Mladost (J) | 1 : 2 | Šamot | |
| 16.05.2021 17:00 | Budućnost | 1 : 2 | Borac | |
| 16.05.2021 11:00 | Gorski Car | 3 : 0 | Brezovac | |
| 16.05.2021 17:00 | Vrbica | 0 : 6 | B 2000 |
| 16.05.2021 17:00 | Aleksa Šantić | 2 : 0 | Polet | |
| 16.05.2021 17:00 | Kula | 0 : 6 | Bratstvo 2019 | |
| 16.05.2021 17:00 | Mladost | 2 : 1 | Lipar | |
| 16.05.2021 17:00 | Jedinstvo | 4 : 3 | Terekveš | |
| 16.05.2021 17:00 | Dinamo 1923 | 1 : 1 | Omladinac | |
| 16.05.2021 17:00 | Dunav | 4 : 3 | Hajduk |
| 16.05.2021 10:00 | OFK Hajduk | 3 : 3 | Vinogradar | |
| 16.05.2021 17:30 | Dinamo | 6 : 0 | Železničar | |
| 16.05.2021 17:30 | Borac (R) | 0 : 1 | Čenej | |
| 16.05.2021 17:30 | Proleter | 5 : 0 | Moskva | |
| 16.05.2021 17:30 | Sloga | 6 : 5 | Slanobarac |
| 16.05.2021 17:00 | Dobrača | 1 : 7 | Bratstvo 1975 | |
| 16.05.2021 17:00 | OFK Žeželj | 1 : 3 | Košutnjak | |
| 16.05.2021 17:00 | Jadran | 5 : 0 | Partizan | |
| 16.05.2021 11:00 | Seljak | 4 : 2 | Divostin |
| 16.05.2021 17:00 | Polet (V) | 3 : 2 | Mlava (B) | |
| 16.05.2021 17:00 | Borac 2016 | 0 : 1 | Napredak (B) | |
| 16.05.2021 17:00 | Ljubičevo | 2 : 0 | Mladi Borac | |
| 16.05.2021 17:00 | Baštovan 2015 | 2 : 3 | Stig 1955 | |
| 16.05.2021 17:00 | Pek | 0 : 3 | BSK 1931 | |
| 16.05.2021 17:00 | Dizel | 4 : 3 | Barič | |
| 16.05.2021 17:00 | Batovac | 6 : 4 | Napredak (P) |
| 16.05.2021 16:30 | Zmaj 1953 | 5 : 2 | Železnik 1930 |
| 16.05.2021 16:30 | Resnik | 3 : 1 | Lepušnica | |
| 16.05.2021 16:30 | Pinosava | 4 : 4 | OFK Crvenka | |
| 16.05.2021 16:30 | Sveti Stefan | 1 : 4 | Minel | |
| 16.05.2021 11:00 | Mladi proleter | 1 : 4 | Palilulac | |
| 16.05.2021 11:00 | Boka Seniors | 0 : 4 | Avala 1939 |
| 16.05.2021 17:30 | Sloga Obrva | 3 : 2 | Mlada krila | |
| 16.05.2021 17:30 | Mladost 1981 | 0 : 1 | Progorelica | |
| 16.05.2021 17:30 | Jedinstvo (G) | 2 : 1 | Jedinstvo (D) | |
| 16.05.2021 17:30 | Lazac | 2 : 1 | Borac (A) | |
| 16.05.2021 17:30 | Zvezda | 2 : 0 | Braća Vuković | |
| 16.05.2021 17:30 | Mladost 1925 | 0 : 0 | Borac (V) |
| 16.05.2021 17:00 | Zadrugar 1947 | 7 : 1 | Radnički (K) | |
| 16.05.2021 17:00 | Sloga 1945 | 2 : 0 | Polet S.D. | |
| 16.05.2021 17:00 | Jedinstvo (K) | 0 : 1 | Sloga 1952 | |
| 16.05.2021 17:00 | Krilaš | 2 : 3 | Bata Bulić | |
| 16.05.2021 17:00 | Mladost (R) | 1 : 0 | Zabrđe 1936 | |
| 16.05.2021 17:00 | Udarnik (S) | 0 : 2 | Pobeda 1953 |
| 16.05.2021 17:00 | Mladost (S) | 3 : 2 | Pomoravlje | |
| 16.05.2021 17:00 | OFK Batinac | 5 : 2 | Beljanica | |
| 16.05.2021 17:00 | Sloga | 8 : 1 | Jasenovo | |
| 16.05.2021 17:00 | Sinđelić | 2 : 1 | Napredak (St) | |
| 16.05.2021 17:00 | Radnički | 4 : 2 | Napredak (Sv) |
| 16.05.2021 17:00 | Sloboda | 1 : 4 | Zenit | |
| 16.05.2021 17:00 | Partizan | 3 : 1 | Šantarovac | |
| 16.05.2021 17:00 | Osaonica | 6 : 0 | Bratstvo | |
| 16.05.2021 17:00 | Jedinstvo | 1 : 1 | GFK Tabane | |
| 16.05.2021 17:00 | Mladost (T) | 2 : 0 | Kupinovac |
| 16.05.2021 17:30 | Ljubinić | 1 : 3 | Skela | |
| 16.05.2021 17:30 | Proleter | 1 : 5 | Partizan | |
| 16.05.2021 17:30 | Belo Polje | 2 : 5 | Borac | |
| 16.05.2021 17:30 | Rvati | 1 : 0 | OFK Urovci |
| 16.05.2021 17:00 | Zvizdar 2012 | 1 : 4 | Kolubara (J) | |
| 16.05.2021 17:00 | Čučuge | 4 : 1 | OFK Paljuvi | |
| 16.05.2021 17:00 | Joševa | 1 : 0 | Proleter (B) | |
| 16.05.2021 17:00 | Polet (DL) | 0 : 3 | OFK Stublenica | |
| 16.05.2021 17:00 | Polet (T) | 4 : 2 | Šarbane |
| 16.05.2021 17:00 | Omladinac | 3 : 0 | Roham | |
| 16.05.2021 17:00 | Terekves | 3 : 2 | Napredak (Č) | |
| 16.05.2021 17:00 | Proleter | 5 : 1 | Napredak (BT) |
| 16.05.2021 11:00 | Mali korak | 1 : 2 | Stari drugari | |
| 16.05.2021 11:00 | Tešnjar | 2 : 0 | Lukavac | |
| 16.05.2021 11:00 | Mladost (L) | 3 : 2 | Toplica | |
| 16.05.2021 11:00 | Žabari | 4 : 0 | Komanice | |
| 16.05.2021 11:00 | Popadić | 2 : 1 | Rakac Stave | |
| 16.05.2021 11:00 | Milenko Pavlović | 6 : 1 | Polet |
| 16.05.2021 17:00 | Mladost (DL) | 1 : 1 | Veliko Trnjane | |
| 16.05.2021 17:00 | Sušica 2012 | 2 : 0 | Badince | |
| 16.05.2021 17:00 | Navalin | 1 : 5 | Lemind 1953 | |
| 16.05.2021 17:00 | Todorovce | 3 : 0 | Turekovac |
| 16.05.2021 17:00 | Supovac | 5 : 3 | Jasenovik 2018 | |
| 16.05.2021 17:00 | Proleter | 10 : 0 | Spartak | |
| 16.05.2021 17:00 | Rujnik | 0 : 3 | Radnički 2020 | |
| 16.05.2021 17:00 | Sloga 1948 | 1 : 1 | Mezgraja |
| 16.05.2021 17:00 | Crvena zvezda | 5 : 1 | Rutevac | |
| 16.05.2021 11:00 | Napredak 2012 | 3 : 2 | Jedinstvo | |
| 16.05.2021 11:00 | Škriljac | 0 : 3 | Polet (R) |
| 16.05.2021 17:00 | Tromedja | 0 : 4 | Graničar | |
| 16.05.2021 17:00 | Bačka | 2 : 0 | Čoka | |
| 16.05.2021 17:00 | Tisa | 2 : 2 | Slavija | |
| 16.05.2021 17:00 | Šampion | 3 : 5 | Potisje | |
| 16.05.2021 17:00 | Jedinstvo | 3 : 0 | Hajduk |
| 16.05.2021 17:00 | Jezava | 1 : 2 | Stari Hrast 2018 | |
| 16.05.2021 17:00 | Omladinac | 2 : 4 | Petlić SD 026 |
| 16.05.2021 11:00 | Mladost (Z) | 1 : 1 | Sloga 1949 | |
| 16.05.2021 17:30 | Hajduk | 6 : 2 | Torpedo | |
| 16.05.2021 17:30 | Verko | 1 : 1 | Polet | |
| 16.05.2021 17:30 | Jedinstvo 2014 | 1 : 1 | Skupljen 2013 | |
| 16.05.2021 11:00 | Bobovik | 3 : 0 | Belpos | |
| 16.05.2021 11:00 | Sparta | 1 : 6 | Mladost 2013 |
| 16.05.2021 17:00 | Mundial | 0 : 2 | Tempo | |
| 16.05.2021 17:00 | Omladinac 1927 | 2 : 4 | Unirea |
| 16.05.2021 16:00 | Gladijator | 0 : 3 | Malba | |
| 16.05.2021 14:00 | Mršinci | 1 : 0 | Budućnost | |
| 16.05.2021 16:00 | Čačak 94 | 3 : 0 | Lugovi | |
| 16.05.2021 16:00 | OFK Remont 1959 | 2 : 4 | Vujan | |
| 16.05.2021 16:00 | Planinac | 0 : 4 | Kej | |
| 16.05.2021 16:00 | Gavrilo Princip | 1 : 3 | Prijatelji |
| 16.05.2021 17:30 | OFK Mala Bosna 2015 | 3 : 1 | Hajduk 1950 | |
| 16.05.2021 17:30 | Žednik | 3 : 1 | Palić | |
| 16.05.2021 17:30 | Čantavir | 0 : 0 | Bikovo | |
| 16.05.2021 17:30 | Solid | 2 : 0 | Elektrovojvodina |
| 16.05.2021 17:30 | Mladost (MB) | 3 : 2 | Orlovi (BP) | |
| 16.05.2021 17:30 | Naša Zvezda | 3 : 0 | Borac (V) | |
| 16.05.2021 17:30 | Slavija | 0 : 4 | Bački Hajduk | |
| 16.05.2021 17:30 | Proleter | 0 : 4 | Krivanj | |
| 16.05.2021 17:30 | Neštin | 4 : 1 | Bačka (D) | |
| 16.05.2021 17:30 | Bačka 1945 | 1 : 2 | Soko |
| 16.05.2021 17:00 | Petrovac 74 | 1 : 6 | Radnički | |
| 16.05.2021 17:00 | Mrovska | 3 : 5 | Šipurske livade | |
| 16.05.2021 17:00 | Vojvoda Stepa Stepanović | 2 : 3 | Jevremovac | |
| 16.05.2021 17:00 | OFK Varna | 1 : 6 | PSK | |
| 16.05.2021 17:00 | Vlašić | 2 : 1 | Pričinović | |
| 16.05.2021 17:00 | Rankovac | 5 : 0 | OFK Jelen | |
| 16.05.2021 17:00 | OFK Letnjikovac 1983 | 2 : 4 | Trešnjevka |
| 16.05.2021 | FC Stella Rossa | 2 : 1 | Semedraž | |
| 16.05.2021 | Šilopaj | 0 : 4 | Jablanica | |
| 16.05.2021 | Velereč 94 | 0 : 0 | Omladinac | |
| 16.05.2021 | Šumadija | 11 : 1 | Takovski Ustanak | |
| 16.05.2021 | Majdan | 2 : 4 | Lunjevica |
| 16.05.2021 17:00 | Mladost | 5 : 1 | Velika Reka | |
| 16.05.2021 17:00 | TE Gučevo | 3 : 2 | 7. Juli | |
| 16.05.2021 17:00 | Antimon | 1 : 1 | Jelav | |
| 16.05.2021 17:00 | Borac | 1 : 2 | Jadar 1961 | |
| 16.05.2021 17:00 | Sloga | 0 : 2 | Prva Iskra | |
| 16.05.2021 17:00 | Jedinstvo (MZ) | 7 : 0 | Hajduk |
| 16.05.2021 17:00 | Kladušnica | : | Egeta | |
| 16.05.2021 17:00 | Pontes | 3 : 0 | Omladinac | |
| 16.05.2021 17:00 | Rtkovo | 3 : 3 | Mala Vrbica | |
| 16.05.2021 17:00 | Lokomotiva | 5 : 1 | Koča Anđelković |
| 16.05.2021 16:30 | Sloga | 2 : 10 | Gorušica | |
| 16.05.2021 16:30 | Bratstvo | 0 : 7 | Brezova | |
| 16.05.2021 16:30 | Jelica | 1 : 3 | Bjelica | |
| 16.05.2021 16:30 | Vrelo | 3 : 1 | Radnički |
| 16.05.2021 17:00 | Omladinac (BO) | 2 : 1 | Mladost | |
| 16.05.2021 17:00 | Torpedo 1924 | 2 : 0 | Omladinac 2013 (SL) | |
| 16.05.2021 17:00 | Budućnost (ZM) | 3 : 2 | Napredak | |
| 16.05.2021 17:00 | Partizan | 2 : 0 | Petlovača | |
| 16.05.2021 17:00 | Sloboda | 4 : 2 | Gorki |
| 16.05.2021 14:30 | Dobrinjac | 1 : 2 | Gorobilje | |
| 16.05.2021 14:30 | Napredak | 1 : 3 | Trešnjica | |
| 16.05.2021 17:30 | Duškovci | 0 : 6 | Plavi Tok | |
| 16.05.2021 17:30 | Glumač | 2 : 1 | Knjaz |
| 16.05.2021 17:00 | Jedinstvo | 3 : 1 | Tomislavci | |
| 16.05.2021 17:00 | Mladost (R) | 1 : 4 | Mladost Radost |
| 16.05.2021 16:30 | Bukovac | 1 : 2 | Udarnik | |
| 16.05.2021 16:30 | Beli Orlovi | 0 : 1 | Palanka | |
| 16.05.2021 16:30 | Budućnost 1948 | 3 : 0 | Šumadija |
| 16.05.2021 16:30 | Omladinac | 7 : 0 | Karadjordje | |
| 16.05.2021 16:30 | Mladost | 1 : 0 | Jedinstvo |
| 16.05.2021 11:00 | Jastrebac 1979 | 5 : 1 | Dobrič 1974 | |
| 16.05.2021 14:00 | Sloga 1980 | 4 : 2 | Jugovići 1976 | |
| 16.05.2021 11:00 | Rad 1974 | 3 : 1 | Arbanasce |
| 16.05.2021 17:00 | OFK Tamnič | 1 : 0 | Vrelo |
| 16.05.2021 11:00 | Naupare | 2 : 1 | Kapidžija | |
| 16.05.2021 17:00 | Konjuh | 1 : 6 | Polet | |
| 16.05.2021 17:00 | Makrešane | 6 : 1 | Bukovica | |
| 16.05.2021 11:00 | Parunovac | 2 : 0 | Modrica |
| 16.05.2021 11:00 | Toplica | 3 : 0 | Knežica | |
| 16.05.2021 11:00 | Grkinja | 2 : 3 | Zaplanjac | |
| 16.05.2021 11:00 | Marina Kutina | 2 : 0 | 10. februar |
| 16.05.2021 16:30 | Umčari | 2 : 1 | Podunavac | |
| 16.05.2021 16:30 | Hajduk | 1 : 1 | Gročanski fudbalski klub |
| 16.05.2021 13:00 | Slemen | 1 : 4 | Palilulac |
| 16.05.2021 17:00 | Jedinstvo | 2 : 6 | Sloga |
| 16.05.2021 20:00 | Parcane | 2 : 3 | Ratajac | |
| 16.05.2021 14:30 | Mladost | 2 : 3 | Stara Čaršija | |
| 16.05.2021 17:00 | Obilić | 3 : 0 | OFK Orašje 1960 | |
| 16.05.2021 17:00 | Borjak 2012 | 3 : 0 | Velika Morava |
| 16.05.2021 17:00 | Borac | 9 : 0 | KSK Konak 1926 | |
| 16.05.2021 17:00 | Sloga | 4 : 5 | Partizan |
| 16.05.2021 17:30 | Morava | 3 : 1 | Stara Čaršija | |
| 16.05.2021 17:30 | Zgodačica | 3 : 5 | BSK 2014 | |
| 16.05.2021 17:30 | Koštam Polje | 6 : 0 | Biljanovac | |
| 16.05.2021 11:00 | Studen Vitez | 2 : 2 | Magnohrom | |
| 16.05.2021 17:30 | Partizan | 2 : 0 | Budućnost | |
| 16.05.2021 11:00 | Omladinac | 3 : 1 | Milakovac 2018 |
| 16.05.2021 17:00 | 27. Oktobar | 1 : 3 | Planinac | |
| 16.05.2021 17:00 | Vojvodina | 2 : 7 | Sloga (K) | |
| 16.05.2021 17:00 | Donji Petrovci | 1 : 5 | Car Uroš | |
| 16.05.2021 17:00 | Borac (J) | 1 : 3 | Jedinstvo (K) | |
| 16.05.2021 17:00 | Fruškogorac | 9 : 1 | Sloga (S) | |
| 16.05.2021 17:00 | Graničar | 4 : 0 | Borac (S) |
| 16.05.2021 11:00 | Dokmir | 4 : 2 | Budućnost 1995 | |
| 16.05.2021 11:00 | Brgule | 0 : 6 | Sloga (V) | |
| 16.05.2021 11:00 | Sovljak | 3 : 2 | Vukona | |
| 16.05.2021 11:00 | Gunjevac | 2 : 1 | OFK Takovo | |
| 16.05.2021 11:00 | Jedinstvo (M) | 4 : 0 | Vrelo |
| 16.05.2021 17:00 | Donja Mutnica | 5 : 0 | BSK Buljane | |
| 16.05.2021 17:00 | Omladinac | 2 : 3 | Radnik | |
| 16.05.2021 17:00 | ISK Izvor | 4 : 0 | Polet |
| 16.05.2021 17:00 | Jedinstvo | 3 : 1 | Budućnost | |
| 16.05.2021 17:00 | Istok 63 | 3 : 0 | Hajduk | |
| 16.05.2021 10:00 | Potočac | 1 : 1 | Heroj |
| 16.05.2021 17:00 | Dinamo (S) | 3 : 0 | Jedinstvo Lemeš | |
| 16.05.2021 17:00 | Telečka | 1 : 2 | Graničar (R) | |
| 16.05.2021 17:00 | Sport | 1 : 7 | Rastina 1918 |
| 16.05.2021 17:30 | OFK Dragoševac | 10 : 0 | Oniks | |
| 16.05.2021 17:30 | Domaćin | 1 : 4 | Trnava | |
| 16.05.2021 17:30 | Napredak | 2 : 3 | Mladi radnik | |
| 16.05.2021 17:30 | Omladinac | 7 : 2 | Dobra Voda |
| 16.05.2021 11:00 | BSK 1924 | 4 : 1 | Napredak 1927 | |
| 16.05.2021 11:00 | Jedinstvo (S) | 4 : 1 | Stig (MC) |
| 16.05.2021 17:00 | Vladimirovac | 3 : 6 | Janošik | |
| 16.05.2021 17:00 | Banatul | 2 : 2 | Rapid |
| 16.05.2021 17:00 | Vinogradar | 2 : 3 | Hajduk | |
| 16.05.2021 17:00 | Pobeda | 2 : 2 | Vitorul |
| 16.05.2021 11:00 | Krćevac 04 | 4 : 2 | Junkovac | |
| 16.05.2021 11:00 | Jarmenovci | 1 : 5 | Budućnost MI | |
| 16.05.2021 11:00 | Maskar | 5 : 4 | Šumadinac 1949 |
| 16.05.2021 17:00 | Udarnik 2015 | 3 : 1 | Napredak | |
| 16.05.2021 17:00 | Omladinac | 1 : 1 | Soko | |
| 16.05.2021 11:00 | Melnica | 0 : 7 | Rudar 1947 |
| 16.05.2021 11:00 | Mladost | 5 : 1 | Radnik 2013 | |
| 16.05.2021 10:30 | Jašunja | 3 : 1 | Rudar 1973 |
| 16.05.2021 17:00 | Jovanovac | 1 : 0 | Kremenac | |
| 16.05.2021 17:00 | Stanovo 1941 | 1 : 2 | Kragujevac | |
| 16.05.2021 17:00 | Hajduk 1936 | 3 : 0 | Bukorovac |
| 16.05.2021 17:00 | Vojvoda Milenko | 5 : 0 | Pobeda | |
| 16.05.2021 17:00 | Napredak 1934 | 4 : 0 | Sloga (D) |
| 16.05.2021 17:00 | Bujačić | 4 : 0 | Mladost |
| 16.05.2021 17:00 | Borac (VR) | 1 : 6 | Srem (SM) | |
| 16.05.2021 17:00 | Planinac | 2 : 1 | Poletarac | |
| 16.05.2021 17:00 | OFK Bosut | 3 : 0 | Borac (R) | |
| 16.05.2021 17:00 | Sloga | 0 : 3 | Srem (SR) |
| 16.05.2021 11:00 | Miloš Pocerac | 0 : 2 | Sava | |
| 16.05.2021 11:00 | Dobrava Žabar 2020 | 6 : 1 | Galeb 1984 | |
| 16.05.2021 11:00 | Rudar | 3 : 3 | Mladost Svileuva | |
| 16.05.2021 11:00 | Korman | 7 : 2 | Borac BTG |
| 16.05.2021 11:00 | Pocerina | 0 : 6 | Maovi MH | |
| 16.05.2021 11:00 | Jedinstvo | 1 : 4 | Zablaće | |
| 16.05.2021 11:00 | Metlić | 3 : 0 | Bojić |
| 16.05.2021 11:00 | Roma - Odžino selo | 3 : 0 | POFK Metaloplastika 2006 | |
| 16.05.2021 11:00 | Napredak | 9 : 0 | POFK Letnjikovac | |
| 16.05.2021 11:00 | Culjković | 3 : 0 | Džemerovac 2020 |
| 16.05.2021 00:00 | BSK | 0 : 1 | Budućnost |
| 16.05.2021 17:00 | Nepričava | 3 : 1 | Izviđač | |
| 16.05.2021 17:00 | Babajić | 16 : 1 | Proleter | |
| 16.05.2021 10:30 | Sloga | 3 : 1 | Stepanje |
| 16.05.2021 17:00 | Stiški Kurjak | 5 : 0 | Radnički (P) | |
| 16.05.2021 17:00 | Sloga-Top | 0 : 4 | Dunavac 1929 |
| 16.05.2021 17:00 | Resava | 2 : 4 | Planinac | |
| 16.05.2021 17:00 | Napredak | 0 : 12 | Vinogradar |
| 16.05.2021 11:00 | Stojan Lazarac | 5 : 2 | Radnik | |
| 16.05.2021 11:00 | Bair | 2 : 3 | OFK Napredak 1933 | |
| 16.05.2021 11:00 | Napredak (U) | 3 : 3 | Mladost |
| 16.05.2021 11:00 | Dvorane | 0 : 2 | Dedina | |
| 16.05.2021 11:00 | Kruševica | 2 : 2 | Padež | |
| 16.05.2021 17:00 | Mladost 2015 | 2 : 6 | Grkljane |
| 16.05.2021 17:00 | Polet | 1 : 4 | OFK Braničevo | |
| 16.05.2021 17:00 | Mrčkovac | 0 : 2 | Mladost |
| 16.05.2021 11:00 | Misača | 4 : 3 | Prvi srpski Ustanak II |
| 16.05.2021 17:00 | Graničar | 0 : 2 | OFK Bingula | |
| 16.05.2021 17:00 | Jedinstvo (Lj) | 5 : 4 | Borac | |
| 16.05.2021 17:00 | OFK Bačinci | 3 : 1 | Omladinac |
| 16.05.2021 | Hajduk 1932 | 4 : 0 | Kupinovo | |
| 16.05.2021 | Mladost 1935 | 3 : 2 | Vitez | |
| 16.05.2021 | Sloven | 2 : 4 | Lovac |
| 16.05.2021 17:30 | OFK Radnički | 3 : 2 | Mladi radnik | |
| 16.05.2021 17:30 | Proleter | 3 : 0 | OFK Polet | |
| 16.05.2021 17:30 | Šumadinac | 4 : 3 | Sloga | |
| 16.05.2021 17:30 | Vreoci | 2 : 2 | Bistrica | |
| 16.05.2021 17:30 | Mladost | 0 : 2 | Dimitrije Tucović |
| 16.05.2021 17:30 | Kolonija | 5 : 0 | Lipar |
| 16.05.2021 17:30 | Jedinstvo | 2 : 2 | Mornar | |
| 16.05.2021 17:30 | Drezga | 1 : 2 | Bokelj | |
| 16.05.2021 17:30 | Ibar | 2 : 3 | Berane | |
| 16.05.2021 17:30 | Igalo | 0 : 1 | Grbalj | |
| 16.05.2021 17:30 | Arsenal | 1 : 2 | Kom |
| 16.05.2021 18:30 | Deportivo Alavés | 4 : 2 | Granada | |
| 16.05.2021 18:30 | Athletic Club | 0 : 1 | Real Madrid | |
| 16.05.2021 18:30 | Atletico Madrid | 2 : 1 | Osasuna | |
| 16.05.2021 18:30 | Barcelona | 1 : 2 | Celta Vigo | |
| 16.05.2021 18:30 | Real Betis | 1 : 0 | Huesca | |
| 16.05.2021 18:30 | Getafe | 2 : 1 | Levante | |
| 16.05.2021 18:30 | Cádiz | 1 : 3 | Elche | |
| 16.05.2021 18:30 | Real Sociedad | 4 : 1 | Real Valladolid | |
| 16.05.2021 18:30 | Valencia | 4 : 1 | Eibar | |
| 16.05.2021 18:30 | Villarreal | 4 : 0 | Sevilla |
| 16.05.2021 20:30 | RB Leipzig | 2 : 2 | Wolfsburg | |
| 16.05.2021 18:00 | Mainz 05 | 1 : 3 | Borussia Dortmund |
| 16.05.2021 21:00 | Bordeaux | 3 : 0 | Lens | |
| 16.05.2021 21:00 | Dijon | 0 : 4 | Nantes | |
| 16.05.2021 21:00 | Lille | 0 : 0 | Saint-Etienne | |
| 16.05.2021 21:00 | Lorient | 2 : 1 | Metz | |
| 16.05.2021 21:00 | Olympique Marseille | 3 : 2 | Angers SCO | |
| 16.05.2021 21:00 | Monaco | 2 : 1 | Rennes | |
| 16.05.2021 21:00 | Montpellier | 0 : 0 | Brest | |
| 16.05.2021 21:00 | Nice | 0 : 2 | Strasbourg | |
| 16.05.2021 21:00 | Nîmes | 2 : 5 | Olympique Lyonnais | |
| 16.05.2021 21:00 | PSG | 4 : 0 | Reims |
| 16.05.2021 20:45 | Milan | 0 : 0 | Cagliari | |
| 16.05.2021 15:00 | Benevento | 1 : 1 | Crotone | |
| 16.05.2021 12:30 | Fiorentina | 0 : 2 | Napoli | |
| 16.05.2021 15:00 | Udinese | 0 : 1 | Sampdoria | |
| 16.05.2021 18:00 | Parma | 1 : 3 | Sassuolo |
| 16.05.2021 17:00 | Spartak | 7 : 0 | Crvena zvezda |
| 16.05.2021 17:00 | Spartak DOO | 3 : 2 | Majdanpek | |
| 16.05.2021 17:00 | Moskva | 2 : 1 | Jedinstvo 2014 | |
| 16.05.2021 13:00 | Heroj Polet | 0 : 4 | ŽGFK Lavice Dubočica | |
| 16.05.2021 16:30 | Loznica | 5 : 1 | Rad |
| 16.05.2021 00:00 | Borac | 3 : 4 | Jedinstvo | |
| 16.05.2021 11:00 | Karađorđe | 2 : 0 | Požega |
| 16.05.2021 | Rudar 1974 | 2 : 4 | Morava |
| 16.05.2021 13:00 | Radnički 2013 | 3 : 0 | Heroj Polet B tim |
| 16.05.2021 17:00 | TSC | 2 : 1 | Vojvodina | |
| 16.05.2021 17:00 | Požarevac | 3 : 3 | Zemun |
| 16.05.2021 11:00 | Partizan | 1 : 2 | TSC | |
| 16.05.2021 11:00 | Vojvodina | 4 : 0 | RFK Novi Sad 1921 | |
| 16.05.2021 11:00 | Radnički 1923 | 3 : 0 | Internacional | |
| 16.05.2021 14:30 | Radnički (N) | 6 : 0 | Trayal |
| 16.05.2021 10:00 | Inđija | 4 : 2 | Radnički 1912 | |
| 16.05.2021 10:00 | Omladinac | 0 : 0 | OFK Bačka | |
| 16.05.2021 10:00 | Spartak ŽK | 2 : 0 | Vojvodina | |
| 16.05.2021 10:00 | Proleter (NS) | 0 : 1 | Železničar |
| 16.05.2021 10:00 | Radnički (NP) | 0 : 3 | Podrinje | |
| 16.05.2021 10:00 | GFK Sloven | 2 : 0 | Radnički (ZR) | |
| 16.05.2021 10:00 | Radnički (SM) | 2 : 3 | Index |
| 16.05.2021 16:30 | Morava (VP) | 1 : 1 | Sloga (K) | |
| 16.05.2021 13:30 | Šumadija (A) | 0 : 0 | BIP | |
| 16.05.2021 13:00 | Budućnost Krušik 2014 | 0 : 1 | Borac 1926 | |
| 16.05.2021 13:30 | GFK Sloboda | 1 : 0 | Šumadija 1903 | |
| 16.05.2021 11:00 | Metalac | 1 : 0 | Loznica | |
| 16.05.2021 12:30 | Jedinstvo (Ub) | 4 : 1 | Radnički (V) |
| 16.05.2021 | OFK Lugomir | 2 : 0 | Jedinstvo (P) | |
| 16.05.2021 | Kopernikus Želežničar | 1 : 2 | GFK Jagodina | |
| 16.05.2021 | Dinamo | 0 : 3 | Real | |
| 16.05.2021 | Radnik | 3 : 0 | Bor 1919 |
| 16.05.2021 12:00 | Smederevo 1924 | 5 : 1 | Napredak | |
| 16.05.2021 11:00 | Sloga 33 | 4 : 3 | VGSK | |
| 16.05.2021 17:00 | Karađorđe | 2 : 0 | OPK Rudar 2001 |
| 16.05.2021 09:30 | BSK 1925 | 0 : 1 | Sinđelić | |
| 16.05.2021 13:30 | Kolubara | 0 : 0 | Lokomotiva | |
| 16.05.2021 17:00 | Bežanija | 1 : 0 | DIF | |
| 16.05.2021 17:30 | Torlak | 0 : 4 | OFK Žarkovo |
| 16.05.2021 10:00 | Poštar 1930 | 2 : 1 | Mladenovac |
| 16.05.2021 11:00 | Zlatibor | 3 : 0 | Korićani |
| 16.05.2021 11:00 | Železničar | 1 : 1 | Mačva 1929 |
| 16.05.2021 10:00 | BSK Borča | 2 : 2 | Rad |
| 16.05.2021 13:30 | Partizan | 5 : 0 | TSC | |
| 16.05.2021 13:00 | Vojvodina | 6 : 0 | Apolon 4 | |
| 16.05.2021 15:00 | Zemun | 1 : 0 | Internacional | |
| 16.05.2021 17:00 | Radnički (N) | 1 : 0 | Real Niš | |
| 16.05.2021 11:00 | Čukarički | 13 : 0 | OFK Vršac | |
| 16.05.2021 10:00 | Crvena zvezda | 4 : 1 | Rad |
| 16.05.2021 12:00 | Inđija | 0 : 3 | Petrika | |
| 16.05.2021 10:00 | Proleter (NS) | 2 : 1 | Radnički (ZR) |
| 16.05.2021 12:00 | OFK Kikinda 1909 | 2 : 2 | Petar Puača | |
| 16.05.2021 12:00 | Spartak ŽK | 4 : 1 | Hajduk 1912 |
| 16.05.2021 12:00 | Radnički (NP) | 0 : 1 | Podrinje | |
| 16.05.2021 12:00 | Omladinac | 4 : 1 | Proleter 2006 | |
| 16.05.2021 12:00 | Radnički (SM) | 1 : 3 | Index | |
| 16.05.2021 10:00 | Železničar | 3 : 0 | OFK Vršac |
| 16.05.2021 18:00 | Ada | 3 : 1 | Kolubara | |
| 16.05.2021 10:00 | OFK Beograd | 4 : 2 | IMT | |
| 16.05.2021 13:00 | Bežanija | 2 : 4 | Studenski grad | |
| 16.05.2021 11:30 | BSK 1925 | 0 : 4 | 011 |
| 16.05.2021 | Radnički (P) | 0 : 3 | GFK Jagodina | |
| 16.05.2021 | SFS Borac | 0 : 3 | Kopernikus Želežničar | |
| 16.05.2021 | Vlasina | 3 : 0 | Dinamo |
| 16.05.2021 10:00 | Balkan | 2 : 1 | Radnički (R) | |
| 16.05.2021 16:30 | Prva Iskra | 2 : 1 | Palilulac | |
| 16.05.2021 17:00 | Vinča | 0 : 4 | Rakovica | |
| 16.05.2021 13:00 | Poštar 1930 | 1 : 6 | RFK Grafičar |