| Kolo | Datum/Vreme | Utakmica | Rezultat |
|---|---|---|---|
| 1 | 03.10.2021 14:00 | Mladost - Niška Banja | 29:28 |
| 2 | 09.10.2021 17:00 | Mladost - BSK Heba | 31:27 |
| 3 | 15.10.2021 20:00 | Aleksinac - Mladost | 34:25 |
| 4 | 24.10.2021 17:00 | Mladost - Pirot | 46:28 |
| 5 | 30.10.2021 18:00 | Žitorađa - Mladost | 24:23 |
| 6 | 07.11.2021 17:00 | Mladost - Rtanj | 28:31 |
| 7 | 14.11.2021 15:30 | Dubočica 54 - 2 - Mladost | 30:32 |
| 8 | 20.11.2021 16:00 | Mladost - Progres | 37:9 |
| 9 | 27.11.2021 19:00 | Knjaz 1957 - Mladost | 29:26 |
| 10 | 06.03.2022 20:00 | Niška Banja - Mladost | 33:23 |
| 11 | 17.03.2022 20:30 | BSK Heba - Mladost | 20:24 |
| 12 | 20.03.2022 14:00 | Mladost - Aleksinac | 26:32 |
| 13 | 26.03.2022 20:30 | Pirot - Mladost | 28:33 |
| 14 | 13.04.2022 17:30 | Mladost - Žitorađa | 28:26 |
| 15 | 10.04.2022 18:00 | Rtanj - Mladost | 31:31 |
| 16 | 28.04.2022 21:00 | Mladost - Dubočica 54 - 2 | 44:30 |
| 17 | 03.05.2022 19:30 | Progres - Mladost | 25:33 |
| 18 | 08.05.2022 14:00 | Mladost - Knjaz 1957 | 27:27 |
| Poz | Tim | Utak | Pob | Ner | Por | DG | PG | GR | Forma | Bod | |
| 1 | Aleksinac | 18 | 16 | 1 | 1 | 579 | 435 | +144 | 1 1 1 X 1 | 33 | |
| 2 | Knjaz 1957 | 18 | 13 | 3 | 2 | 623 | 531 | +92 | 1 1 1 1 X | 29 | |
| 3 | Niška Banja | 18 | 12 | 1 | 5 | 604 | 545 | +59 | 2 1 1 2 1 | 25 | |
| 4 | Rtanj | 18 | 11 | 2 | 5 | 594 | 511 | +83 | 2 X 1 X 2 | 24 | |
| 5 | Mladost | 18 | 10 | 2 | 6 | 546 | 492 | +54 | 1 X 1 1 X | 22 | |
| 6 | Žitorađa | 18 | 8 | 0 | 10 | 524 | 539 | -15 | 2 1 2 1 2 | 16 | |
| 7 | Dubočica 54 - 2 | 18 | 5 | 0 | 13 | 642 | 685 | -43 | 2 2 2 1 2 | 10 | |
| 8 | BSK Heba | 18 | 4 | 1 | 13 | 522 | 605 | -83 | 2 2 2 2 1 | 9 | |
| 9 | Pirot | 18 | 4 | 0 | 14 | 524 | 626 | -102 | 1 2 2 2 1 | 8 | |
| 10 | Progres | 18 | 2 | 0 | 16 | 437 | 626 | -189 | 1 2 2 2 2 | 4 | |
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